Heme Flashcards
Causes of microcytic (<80 fL= MCV) anemia
Iron deficiency (late) ACD (late) Thalassemias Lead poisoning Sideroblastic anemia
Causes of Non-Hemolytic, Normocytic (MCV= 80-100) anemia
ACD (early)
Aplastic anemia
Chronic Kidney Disease
Iron deficiency (early)
Causes of Intrinsic Hemolytic, Normocytic (MCV= 80-100) anemia
Hereditary spherocytosis G6PD Deficiency HbC Paroxysmal nocturnal hemoglobinuria Sickle cell anemia
Causes of Extrinsic Hemolytic, Normocytic (MCV= 80-100) anemia
Autoimmune
Microangiopathic
Macroangiopathic
Infections
Causes of Megaloblastic Macrocytic (MCV >100 fL) anemia
Folate deficiency
B12 deficiency
Orotic aciduria
Causes of Non-Megaloblastic Macrocytic (MCV >100 fL) anemia
Liver disease
Alcoholism
Reticulocytosis
t(9;22)
CML
t(8;14)
Burkitt lymphoma
t(11;14)
Mantle cell lymphoma
t(14;18)
Follicular lymphoma
t(15;17)
M3 type of AML
Bcr-abl
CML
Bcl-2
Follicular lymphoma
C-myc
Burkitt lymphoma
Cyclin D1
Mantle cell lymphoma