GPCR Flashcards
1
Q
List All Gq
A
“Q can HAVe 1 M&M”
H1, Alpha1, V1, M1, M3
2
Q
List all Gi
A
“MAD 2s”
M2, Alpha2, D2
3
Q
List all Gs
A
Beta1, Beta2, D1, H2, V2
4
Q
Receptor that:
- Increases SM contraction
- Increases pupillary dilator contraction
- Increase intestinal and bladder sphincter muscle contraction
A
Alpha1
5
Q
Receptor that:
- Decreases HR
- Decreases contractility of atria
A
M2
6
Q
Receptor that:
- Increases nasal and bronchial mucus production
- Increases vascular permeability
- Contracts bronchioles
- Causes pruritis/pain
A
H1
7
Q
Receptor that:
-Increases H2O permeability and reabsorption in collecting tubules of kidney
A
V2 (found in 2 kidneys)
8
Q
Receptor that causes:
- Vasodilation
- Bronchodilation
- Increased HR
- Increased contractility
- Increased lipolysis
- Increased insulin release
- Decreased uterine tone (tocolysis)
- Ciliary muscle relaxation
- Increased aqueous humor production
A
Beta-2
9
Q
Receptor that causes:
- Decreased sympathetic outflow
- Decreased insulin release
- Decreased lipolysis
- Increased platelet aggregation
A
Alpha-2
10
Q
Receptor that causes:
- Increased exocrine gland secretions (ex. lacrimal, salivary, gastric acid)
- Increased gut peristalsis
- Increased bladder contraction
- Bronchoconstriction
- Increased pupillary sphincter contraction (miosis)
- Ciliary muscle contraction (accommodation)
A
M3
11
Q
Receptor that causes:
-Relaxed renal vascular SM
A
D1
12
Q
Receptor that causes:
-Increased vascular SM contraction
A
V1
13
Q
Receptor that modulates transmitter release (especially in brain)
A
D2
14
Q
Receptor that:
- Increases HR
- Increases contractility
- Increases Renin release
- Increases lipolysis
A
Beta-1
15
Q
Receptor that works in CNS and enteric nervous system
A
M1
