Renal Proximal Tubule And The Loop Of Henle Flashcards
What is reabsorbed in the proximal tubule
Sugars Amino acids Phosohate Sulphate Lactate
What is secreted in the proximal tubule
Hydrogen ions Hippurates Neurotransmitters Bile pigments Uric acid Drugs Toxins
What is trans cellular
Though the cell
What is para cellular
Betweent he epithelia cells
What is primary active transport
Energy is directly required to operate the carrier and move the substrate against its conc grad
What is secondary active trans
Carrier mol transported coupled to conc grad of an ion usually sodium
What is facilitated diffusion
Passive carrier mediated transport of a substance down its conc grad
Where are sodium pottasium pumps found
Basolateral mem
How does isoosmotic fluid reabs across leaky proximal tubule epithelia occur
Standing osmotic grad
Oncotic pressure grad
What is glucose abs in proximal tubule
100% of glucose in filtrate reabs in proximal tubule
What is the transport maximum of glucose
2mmol/min
67% of what is reabs in PT and what is reabs 100%
67% - salts water
100% - glucose and amino acids
What is the function of the loop of Henle
Generate a cortico-medullary solute conc grad
Form hypertonic urine
What is the fluid flow like in the loop of Henle
Opposing flow in two limbs countercurrent flow
The entire loop = countercurrent multiplier
Together the loop and vasa recta establish a hyper-osmotic medullary interstitial fluid
What happens along the ascending limb of the lop of Henle
Along entire length sodium a dn chloride reabs
In ticker parts this is done via active trans while done by passively in thinner parts
This part is relatively perm to water this inflicts upon salt reabs
What happens in the descending loop of Henle
Does not reabs sodium chloride highly preamble to water
Where is the triple co transporter and what does this do
On luminal surface of epi cell
Moves sodium, pottasium and chloride into cell
What does pottasium recycling mean
Means that sodium chloride is abs into interstitial fluid
What does loop dietetics do to triple co transporter
Blocks it
How does urea pass into loop
Passively diffuse
What does ureas
Do to the interstitium
Adds solute
Where is not preamble to urea
Distal tubule
What is the purpose of the countercurrent multiplication
To concentrate the medially interstitial fluid
Why is he medulla interstitial fluid concentrated
To enable kidneys to produce urnie to diff volume and concentration according to amounts of circulating ADH
What happens to the blood osmolarity as the loop of Henle dips into medulla and back up
Osmolarity rises as dips into medulla as water lost and salt gained
Osmolarity falls as loop up into cortex as water gained and the solute lost
What acts as a countercurrent exchanger
The vasa recta
What is the vasa react fully perm to
Nacl and water
What creates the medullary osmotic grad
Countercurrent multiplier
Urea cycle
This gradientpreserved by countercurrent exchanger
The fluid reabs in the proximal tubule is what with filtrate
iOS osmotic
