Renal Control Of Body Fluid Volume And Osmolarity Flashcards
What kind of hormone is ADH
Neurohomone
Where is ADH produced
In the hypothalamus
How does ADH work roughly
Form hypothalamus
Down axons
Posterior pituitary
How is the need for ADH production detected
Osmoreceptors
What effect does the ADH have on the permeability of the distal tubule
ADH from the blood
Bind to type 2 vasopressin receptor at basolateral mem
Cell signal = cyclic amp production
Aquaporin produced at apical mem
What is diabetes insipidus
Hereditary disorder which causes individual to produce large volumes of dilute urine, constantly thirsty,
Treat = ADH supplement
What are the two types of diabetes insipidus and what do they mean
Central - cannot make ADH
Nephrogenic- can make ADH as norm,a but cannot exert its affect on target cells
What is the secondary production site of ADH
Left atrial stretch receptors
What do the stretch receptors in the GI tract do
Forward feeding activation or inhibition of ADH
Too much fluid activate ADH
Too little inhibit ADH
What is aldosterone
Steroid hormone
Wher is aldosterone produced
Adrenal cortex of adrenal gland
How does the body cope with the changes in body fluid volume
Filtration –> changes in blood pressure and size of filtration slits
Secretion and re absorption –> changes in solution concentration
Excretion –> bladder function under renal control
What does aldosterone do
Stimulates sodium reabs and pottasium sec
When is aldosterone sec
Response to rising pottasium in las a conc of blood
If decrease in sodium
What are the granular cells of the juxtmedullary sensitive to
Afferent arteriole pressure
If there is an increased symp activity as a result of reduced arterial blood pressure what would this mean
Granular renin sec cells are directly innervated by symp nervous system causes renin release
What can abnormal increases in RAA system increase
Hypertension
What produced atrial natriuretic peptide ANP
Heart produces and stored in atrial smooth muscle
When is ANP released
When the smooth muscle cells are stretched due to increased plasma volume
What does ANP do
Promote excretion of sodium osmotic effect and dieresis decreasing plasma volume
Effect CVS to lower blood pressure
What happens in water dieresis
Increased urine flow but not an increased solute excretion
What happens in osmotic dieresis
Increased urine flow is as result of a primarily increase in salt excretion
