Renal Pathophysiology and Disorders

Question 1

significant acute kidney injury and haemoptysis

top 3 differentials?

Answer 1

goodpastures
microscopic polyangitis
granulomatosis with polyangitis

Question 2

antibody for goodpasture?

Answer 2

anti-GBM

Question 3

antibody for microscopic polyangitis?

Answer 3

p-ANCA (or MPO antibodies)

Question 4

granulomatosis with polyangiitis

Answer 4

c-ANCA (or PR3 antibodies)

Question 5

Rapidly progressive glomerulonephritis

histology findings?

Answer 5

glomerular crescents.

Question 6

It involves immune complex deposits and mesangial proliferation

Answer 6

Membranoproliferative glomerulonephritis

Question 7

Membranous nephropathy

Answer 7

IgG and complement deposits on the basement membrane

2^ SLE / malignancy / drugs nsaids

Question 8

renal tubular acidosis which is the most common type?

Answer 8

type 4

low aldesterone

or impaired aldosterone function

Question 9

urinary pH and serum potassium results for type 4?

Answer 9

low urinary pH

high serum potassium

Question 10

RTA causes _____, ____

the pathology is in the ____

Answer 10

metabolic acidosis

tubules of the kidneys which balance hydrogen and bicarbonate ions

Question 11

Type 1 RTA?

Answer 11

distal tubule cannote excrete hydrogen ions

Question 12

Type 2 RTA?

Answer 12

proximal tubule cannot reabsorb bicarbonate

Question 13

how is type 4 renal tubular acidosis managed?

Answer 13

increase aldosterone deficiency
> fludrocortisone
>oral bicarb
> treat hyperkalaemia