Radiotherapy and Chemotherapy in Gynae Cancer

Question 1

what oncoproteins mediate the development of cervical cancer?

Answer 1

E6 and E7

Question 2

what is the difference between stage 1 and 2 cervical cancer?

Answer 2

the cancer has extended very locally eg to vagina/parametrium

Question 3

Tx cervical cancer?

Answer 3

lletz and cone biopsy if v early
trachelectomy if early + fertility sparing
hysterectomy + lymphadenectomy
radiotherapy +++
chemo

Question 4

chemo drugs used? how often per week?

Answer 4

cisplatin 40mg/m2 per week

carboplatin

Question 5

what is brachytherapy?

Answer 5

inserting radioactive material directly into the affected area

Question 6

risk factors for endometrial cancer?

Answer 6

obesity
oestrogens eg HRT
genetic eg lynch syndrome

Question 7

Ix ovarian cancer

Answer 7

serum CA125
TV/TA USS
pleural fluid/ascites for cytology

Question 8

where does OC metastasise to?

Answer 8

liver
lungs
brain

Question 9

chemo Tx ovarian cancer?

Answer 9

1. carboplatin

2. carboplatin + paclitaxel

Question 10

when would you consider chemo in early stage ovarian cancer?

Answer 10

if they are a high grade

Question 11

those with the BRCA mutation tend to respond well to what type of chemo?

Answer 11

platinum based eg carboplatin

Question 12

those with the BRCA mutation tend to get what kind of ovarian cancer?

Answer 12

papillary serous