quinolones

Question 1

what is the class of this drug

Answer 1

nucleic acid synthesis inhibitor

Question 2

agents

Answer 2

ciprofloxacin, levofloxacin, moxifloxcin

Question 3

what is the mechanism

Answer 3

inhibits DNA gyrase, and topoisomerase dont allow the enzyme to reseal the DNA.

Question 4

resistance mechanism

Answer 4

alter target genes, efflux pump, cell membrane permeability

Question 5

spectrum

Answer 5

gram (+): in vitro action against aureus, s. pneumoniae, enterococcus but poorly. gram (-): GNRs, e coli, klebsiella, proteus, h flu, p. aeruginosa. atypicals, mycobacterium, anaerobes,

Question 6

clinical uses

Answer 6

UTI (cystitis, pyelonephritis, prostatitis), GI and abdominal (travels diarrhea, or infection), respiratory tract infections (CAP, HAP, cystic fibrosis), bone and joint infection (osteomyelitis, prosthetic infection), cutaneous anthrax, MDR TB

Question 7

adverse affects

Answer 7

mild GI, CNS (HA, dizziness, confusion), tendonitis, tendon rupture, qt prolongation

Question 8

drug interactions

Answer 8

chelates with iron, aluminum, magnesium, calcium, sucralfate. cipro inhibits CYP1A2 which decreases clearance of theophyline, tizanidine as well.