macrolides Flashcards
1
Q
agents
A
azithromycin, erythromycin, calrithromycin
2
Q
mechanism of action
A
reversible interaction with the 50s subunit of the ribosome.
3
Q
resistance to the macrolides
A
decreased permeability (enterobacter), alteration in the binding site, enzymatic inactivation, alteration in the 23s ribosomal subunit.
4
Q
spectrum of the macrolides
A
atypicals (legionella, chlamydia, mycoplasma); gram (+): s. pneumoniae; gram (-): h flu, catarrhalis; anaerobes: actinomyces.
5
Q
clinical uses
A
uncomplicated U/L-RTI, mycobacterial infections (avium), h. pylori
6
Q
adverse affects
A
GI (E>C>A), hepatic events are rare. QT prolongation,
7
Q
drug interactions
A
clarithromycin and erythromycin potent inhibitors of CYP3A.
8
Q
course of treatment
A
short, due to azythromycins long half life.
