GI drugs I Flashcards
what is the cause of ulcers
increased acidity or decreased mucosal resistance. caused or promoted by gastric acid
where is a peptic ulcer located
in the duodenum
what three receptors are present on the parietal cell in the stomach and what do they do?
gastrin, Ach, and histamine. all act to stimulate the K+/H+ ATPase.
what does histamine do the cell
increases the formation of cyclic AMP
what does gastrin and cholinergics do the parietal cell
increases intracellular calcium
where does gastrin come from in the stomach
the antrum
where does Ach come from in the stomach
from vagal input
where does histamine come from in the stomach
stimulated by both Ach and gastrin
define the mucosal protection from acid
there is a pH gradient from very low, to 7 caused by the secretion of bicarbonate. this protects the mucosa from damage. there is reduced bicarb secretion in DU patients.
what is the approach to treating ulcers
relief of symptoms, promotion of healing, prevention of complications, prevention of recurrence.
what is the treatment plan for ulcers
neutralize acid, decrease acid production, increase resistance
antacid therapy
only effective when they can elevate the pH to above 5. stops pepsins damage as well as acidic erosion. best if taken 1 hour after eating when gastrin activity is highest. liquids work better
calcium carbonate
reacts slowly with HCl to form calcium chloride and carbonic acid. it is constipating so given with magnesium compounds as laxatives
what are the SE of calcium carbonate
milk-alkali syndrome, nephrocalcinosis, rebound acidity, digitalis antagonism d
sodium bicarbonate
rarely used because of systemic alkalosis, enhanced effects of amphetamine, quinidine, cinchophen. high sodium content
magnesium hydroxide and carbonate
hydroxide is more potent. may cause magnesium intoxication in renal disease.
magnesium hydroxide and carbonate SE
diarrhea, hypokalemia, hypermagnesemia, iron deficiency
aluminum hydroxide
combines to form al-Cl and water. aluminum is excreted in the feces when it combines with phosphate. this is also useful in protecting the mucosa and doesnt perturb the electrolytes in the body. useful in renal patients.
adverse of effects of aluminum chlorides
constipation, phosphate depletion, weakness, anemia, tetany, apnea, delayed gastric emptying, concretions, fecaloma, perforation, peritonitis, encephalopathy. impaired absorption of tetracycline and digoxin.