oxazolidinones Flashcards
1
Q
agents
A
linezolid, tedizolid
2
Q
mechanism of action
A
bind to 23s rRNA of the 50s subunit and inhibits sythesis
3
Q
resistance
A
rare. through mutation
4
Q
spectrum
A
gram (+): s. aureus (MRSA, MSSA), enterococcus (VRE), coagulat (-) staph, streptococci.
5
Q
does this work against gram (-)
A
no
6
Q
does this work against anaerobes
A
poorly
7
Q
clinical uses
A
gram (+) alternative. VRE
8
Q
adverse for linezolid
A
reversible myelosuppression. thrombocyto common. usually after 2 weeks of therapy
9
Q
drug intereactions
A
reversible inhibitor of MOA. can result in serotonin syndrome
