glycyclines Flashcards

1
Q

what is the agent

A

tigecycline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what is the mechanism

A

derivative of minocycline that enhances ribosomal permeation and binding. it overcomes the efflux pump and ribosomal protection. lk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

is this drug bacteriocidal

A

no its bacteriostatic because the interaction with the ribosome is reversible

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

spectrum

A

broad. negative, positive, anaerobes, includes MRSA, VRE, acinetobacter. atypicals.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what does this not treat

A

providencia, proteus, pseudomonas.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

clinical uses

A

complicated skin infections and soft tissue, intra-abdominal, MDR infections (CRE),

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what are the adverse affects

A

GI nausea/vomiting, diarrhea, increased LFTs,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is this not used for?

A

bacteremia due to its tissue distribution, there is actually a low concentration in the serum.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly