aminoglycosides Flashcards

1
Q

what is the class of these drugs

A

protein synthesis inhibitors that work on the 30s ribosomal subunit

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2
Q

what drugs are in this subclass

A

gentamycin, amikacin, tobramycin, streptomycin.

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3
Q

mechanism of action

A

oxygen dependent active transport across the membrane binds to 30s subunit and interferes with the initiation complex. inhibits protein synthesis.

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4
Q

what is the resistance to these drugs>

A

reduced uptake or decreased permeability, altered ribosomal binding sites, enzymatic alteration.

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5
Q

spectrum

A

gram (+) active against enterococcus. cannot give as monotherapy. gram (-): enterobactericae, pseudomonas.

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6
Q

what do these drugs not work on?

A

anaerobes.

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7
Q

clinical uses

A

gram (-) sepsis, UTI, sombination with ampicillin, vancomycin for enterococcal. combine with penicillin for viridans endocarditis

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8
Q

how are these drugs eliminated

A

almost exclusively by the urine

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9
Q

what are the SE

A

nephrotoxic. ototoxic (risk increased with loop diuretic). neuromuscular block.

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