PT hepatic issues Flashcards

1
Q

What is the function of the liver

A
  • production of bile to help carry away waste products
  • regulation of glucose, hormones, and vitamines
  • metabolizes drugs, alcohol and chemicals
  • production of proteins for blood plasma and regulation of blood clotting
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2
Q

What are common physical signs of liver disease

A
  • hepatomegaly
  • spider angiomas/nevi
  • Jaundice
  • ascites
  • gynecomastia
  • carpal tunnel syndrome (back up of fluid)
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3
Q
A
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4
Q

review pathology

A
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5
Q

What is hepatic encephalopathy

A
  • poor liver function leads to accumulation of ammonia
  • ammonia is a neurotoxin
  • damages astocytes
  • can lead to cerebal edema, inceased in intacranial perssure
  • assoicated with increased incidence of intarcerebral hemorrhage
  • severity graded by 0-4
  • minimal cognitive changes to coma
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6
Q

What are some causes of hepatic encephalopathy

A
  • renal failure/dysfunction
  • GI bleeding
  • infection
  • constipation (contibutes to another dysfunction)
  • medications
  • diuertics
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7
Q

What are some causes of liver disease/dysfunction

A
  • hepatitis
  • drug induced injury/hepatotoxicity
  • alcoholic liver disease
  • non-alcoholic fatty liver disease
  • autoimmune disease (autoimmune hepatitis can affect bile ducts)
  • pregnancy induced
  • vascular
  • neoplasm
  • pyogenic liver abscess
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8
Q

Describe the types of hepatitis

how are they transmitted/is there a vaccine

A
  • HAV: transmission though oral-fecal and there is a vaccine
  • HBV: trasmission through sex, skin puncture, with a vaccine
  • HCV: transmission though injection drug use; no vaccine
  • HDV: transmission with co-infection with HBV; HBV vaccine
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9
Q

common signs and prognosis for hepatitis

A
  • jaudice, fever
  • prognosis varies from recovery to chronic liver disease
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10
Q

How to address non-alcoholic fatty liver disease

A
  • goal to prevent long-term liver damage and sequelae: reduce liver fat
  • overall weight loss 3-10% of body weight may help
  • weight loss needs to occur with health diet changes
  • long-term damage can lead to end stage liver disease
  • lifestyle interventions
  • dietary resriction: processed foods, sugarry foods, complex carbs
  • increased physical activity
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11
Q

What is hepatopulmonary syndrome

A
  • defect in arterial oxygenation caused by intrapulmonary vascular dilations in the context of liver disease
  • prevalence in patients who are candidates for liver transplant (4-32%)
  • diagnosed with arterial blood gas and transthroacic echocardiogaphy
  • liver disease caused inflammatory response in lungs
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12
Q

Mechanism of hepatopulmonary syndrome

A
  • endotoxemia: liver isnt clearing toxins well
  • causes movement of intestinal bacteria into body
  • increase of macrophages and monocytes in lungs
  • results in increase TNF and NO (inflammation/vasodilation)

overall: ventilation-pefusion mismatch, mos significant in base of lungs

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13
Q

How can hepatopulmonary syndrome by staged

A
  • Mild: PaO2= ≥80 mmHg
  • moderate = PaO2 60-79 mmHg
  • Severe = PaO2 50-59 mmHg
  • Very sever = PaO2 < 50 mmHg

important factor related to time to transplant and prognosis

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14
Q

Clinical manifestations of hepatopulmonary syndrome

A
  • dyspnea: at rest or exertion
  • platypnea orthodeoxia: worsening symptoms in upright positioning
  • digitla clubbing
  • normal chest radiographs
  • rarely: cyanosis
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15
Q

how does HPS differ from common lung disease

A
  • driven by liver disease
  • preservation of lung tissue
  • no changes on imaging
  • platypnea orthodoeoxia
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16
Q

what is the medical treatment for HPS

A
  • supplemental oxygen for symptom management
  • liver transplant
  • transplant only effective long term teatment
  • will no qualify for transplant if too severe (< 40 mmHG)
17
Q

outcomes fo medical treament/transplantation for HPS

A
  • longer mechanical ventilation time, an increase need for non-invasive ventilation, longer intensive care unit stay and longer hospital stay
  • five year survival rate 76%
  • resolution of gas exchange abnormalities can occur in 6 to 12 months abnormalities can persist after 12 months
  • mortality with or without transplant is highest in patients with PaO2 < 50 mmHg
18
Q

Premature infants, fractures and nutrition

A
  • premature infants are among those at highest risk for hospital acquired fractures
  • about 1/3 of ELBW neonates sustained fracutres
  • nutritional prevention and treatment important
  • attempting to mimic in utero nutrition
  • TPN: may help increase intake of nutrients and minerals improving growth and lowering risk of fractur
19
Q

nutritional considerations for geriatric population

A
  • changes in nutrition requirements
  • changes in lean body mass
  • sacropenia/osteosacropenia
  • physical impairments: dentition
  • comorbidities
  • psychosocial and cognitive changes
20
Q

nutritional screening and PT

A
  • screen for overweight and obesity
  • BMI, waist circumference, risk factors for disease assoicated with obseity
  • screen for under nutrition: mini nutritional assessment tool
  • dietary changes/refferrals to dietitians
21
Q

PT exam with nutrition

A
  • appearance nad postural analysis
  • motor and sensory function
  • functional activities
  • gait, endurance, and postural control
  • egress test
22
Q

RA and nutrition

A
  • anti-inflammatory diet may be helpful for RA and other conditions with chronic inflammation
  • omega -3 fatty acids
  • capsaicin
  • ginseng
  • cocoa
  • Vit D
23
Q

What is important parts of an anti-inflammatory diet: fruits/veggies

A
  • 3-4x more veggies than fruit
  • 1-2 servings/color/day variety
  • antioxidants neutralize oxidative stress
  • minerals, vitamins, fibers, polyphenols
  • intake inversely coorrrelated with obesity and inflammation
  • legumes and beans
24
Q

whole grains: anti-inflammatory diet

A
  • affects microbiome and immune function via Short chain fatty acid production
  • reduces oxidative stess and inflammation
  • grain with 1 ingredient only
25
Q

foods that promote inflammation

A
  • processed foods
  • refined starches and grains
  • sugar