Protein Synthesis Inhibitors

Question 1

What are main groups of the protein synthesis inhibitors?

Answer 1

30S + 50S

Question 2

What are the groups under 30S inhibitors?

Answer 2

1. Tetracycline
2. Glycylcyclines
3. Aminoglycosides

Question 3

What are the groups under 50S inhibitors?

Answer 3

1. Macrolides/Ketolides
2. Chloramphenicol
3. Lincosamide
4. Quinupristin/Dalfopristin
5. Linezolid

Question 4

What are the tetracyclines?

Answer 4

1. Demeclocycline
2. Doxycycline
3. Minocycline
4. Tetracycline

Question 5

What are the glycylcyclines?

Answer 5

Tigecycline

Question 6

What are the aminoglycosides?

Answer 6

1. Gentamicin
2. Amikacin
3. Neomycin
4. Streptomycin
5. Tobramycin

Question 7

What are the AB that can be utilized via inhalation?

Answer 7

Aztreonam and Tobramycin

Question 8

What are the macrolides?

Answer 8

1. Azithromycin
2. Clarithromycin
3. Erythromycin

Question 9

What are the ketolides?

Answer 9

Telithromycin

Question 10

What is the spectrum of activity of Tetracyclines?

Answer 10

1. Broad coverage
2. Rickettsiae
3. Spirochetes (Lyme disease)
4. Mycoplasma
5. Chlamydia

Question 11

What is the drug of choice for treating Rocky Mountain spotted fever?

Answer 11

Doxycycline

Question 12

Which tetracyclines can be used against MRSA?

Answer 12

Doxycycline + Minocycline

Question 13

What is the condition that you may get from using outdated TCN?

Answer 13

Fanconi syndrome

Question 14

What are the AE of TCNs?

Answer 14

1. Photosensitivity

2. Discoloration of teeth in children

Question 15

What interactions occur w/ TCNs?

Answer 15

1. Divalent or Trivalent cations
2. Milk/calcium products
   * *take RX 2 hrs before or after

Question 16

What is the spectrum of activity of Tigecycline?

Answer 16

MRSA + VRE, G-, and Anaerobes

Question 17

What is the spectrum of activity of Aminoglycosides?

Answer 17

G- and G+, Aerobe, P. aeruginosa

Question 18

Aminoglycosides are considered (bactericidal/bacteriostatic) in a concentration-dependent manner

Answer 18

Bactericidal

Question 19

Do Aminoglycosides display post antibiotic effect?

Answer 19

Yes

Question 20

How often are Aminoglycosides dosed?

Answer 20

QD

Question 21

What is the MOA of Aminoglycosides?

Answer 21

Interferes w/ initiation of protein synthesis by fixing 30S-50S complex at start codon, induces misreading of mRNA, and incorporating incorrect AA

Question 22

In what form are aminoglycosides available?

Answer 22

IV only

Question 23

What are the distribution patterns for Aminoglycosides?

Answer 23

1. Doesnt enter CSF

2. Distributes poorly into adipose tissue (adjust for body weight dosing)

Question 24

What are the AEs of Aminoglycosides?

Answer 24

1. Ototoxicity
2. Nephrotoxicity (gradual rise in BUN and serum creatinine)
3. Neuromuscular blockade

Question 25

What kind of coverage does Erythromycin have?

Answer 25

Good G+ coverage

Little G- coverage

Question 26

What kind of coverage does Azithromycin have?

Answer 26

Adds more G- coverage compared to Erythromycin + covers Mycobacterium avium-intracellulare

Question 27

What kind of coverage does Clarithromycin have?

Answer 27

Adds more G- coverage compared to Erythromycin + covers Mycobacterium avium-intracellulare

Question 28

What kind of coverage does Telithromycin have?

Answer 28

Adds more coverage and S.

Pneumoniae and S. aureus compared to Erythromycin

Question 29

What is the common coverage amongst the Macrolides/Ketolides?

Answer 29

1. Legionella pnuemophilia
2. Chlamydia sp.
3. Mycoplasma sp.

Question 30

What is another Macrolide used to treat Clostridium difficile-associated diarrhea?

Answer 30

Fidaxomicin

Question 31

Which Macrolide/Ketolides MUST be taken on an empty stomach?

Answer 31

Azithromycin

Question 32

Which Macrolide/Ketolide is discontinued in the U.S.?

Answer 32

Telithromycin

Question 33

Which Macrolide/Ketolide is NOT metabolized by P450 3A4?

Answer 33

Azithromycin