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Infectious Disease > Hepatitis > Flashcards

Hepatitis Flashcards

1
Q

What is Hepatitis B susceptible to?

A

Bile acid lysis

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2
Q

Which pegylated IFN treats HBV?

A

pegIFN a2a

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3
Q

What is the MOA of IFN for HBV treatment?

A

Acts as host cytokine

Has antiviral, antiproliferative, and immunomodulatory effects

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4
Q

What are some warnings associated w/ Adevovir Dipivoxil?

A
  1. Nephrotoxicity

2. Increase of serum creatinine

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5
Q

Telbivudine is a(n) _______ analogue with potent anti-HBV activity

A

L-nucleoside

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6
Q

Hepatitis is a (DNA/RNA) virus

A

DNA, partially double stranded

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7
Q

Interferon alpha AE?

A
  1. Flu-like symptoms
  2. Neuropsychiatric events
  3. Risk for infection
  4. Increased liver enzymes
  5. Stevens-Johnson Syndrome
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8
Q

Sofosobuvir AE?

A

Rash + pruritus + anemia

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9
Q

For HCV, what class does Sofosobuvir belong to?

A

NS5B inhibitor

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10
Q

What are the main treatments for HBV?

A

IFN (standard or pegylated)

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11
Q

For HCV, what class does Grazoprevir belong to?

A

Protease inhibitor

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12
Q

Ribavirin MOA and what is it used against?

A

Inhibits RNA polymerase + inhibits initiation/elongation of RNA fragments

For HCV

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13
Q

Interferon alpha MOA?

A

Naturally producing cytokine that has antiviral, antiproliferative, and immunomodulatory effects

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14
Q

What drugs are made up in the NS5B inhibitor class used against HCV?

A

End w/ “buvir”

  1. Sofosobuvir
  2. Dasabuvir
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15
Q

What is the MOA of Lamivudine?

A

Inhibits DNA polymerase

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16
Q

Which RX inhibits lamivudine resistant HBV?

A

Adefovir Dipivoxil, Entecavir, or Telbivudine

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17
Q

For HCV, what class does Dasabuvir belong to?

A

NS5B inhibitor

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18
Q

For HCV, what class does Elbasvir belong to?

A

NS5A inhibitor

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19
Q

For HCV, what class does Paritaprevir belong to?

A

Protease inhibitor

20
Q

NS5A inhibitor MOA?

A

Binds to N terminus within domain 1 to inhibit replication + assembly

21
Q

For HCV, what class does Ledipasvir belong to?

A

NS5A inhibitor

22
Q

For HCV, what class does Daclatasvir belong to?

A

NS5A inhibitor

23
Q

For HCV, what class does Simeprevir belong to?

A

Protease inhibitor

24
Q

Rivavirin AE?

A
  1. Hemolytic anemia
  2. CNS effects
  3. GI effects
  4. Dermatologic effects
  5. Neuromuscular effects
25
Q

What is the MOA of Adefovir Dipivoxil?

A

Inhibits DNA polymerase

26
Q

Which standard IFN treats HCV?

A

IFN a2a or IFN a2b

27
Q

What drugs are made up in protease inhibitors that are used against HCV?

A

End w/ “previr”

  1. Grazoprevir
  2. Paritaprevir
  3. Simeprevir
28
Q

Protease inhibitors used for HCV, AE?

A
  1. General stuff

2. Skin photosensitivity + rash

29
Q

What is the first line therapy for chronic HBV?

A

Entecavir + Tenofovir

30
Q

Which pegylated IFN treats both HBV and HCV?

A

pegIFN a2a

31
Q

Which treatment of HBV can develop resistance as a result of prolonged treatment?

A

Lamivudine + Telbivudine

32
Q

For HCV, what class does Ombitasvir belong to?

A

NS5A inhibitor

33
Q

For HCV, what class does Velpatasvir belong to?

A

NS5A inhibitor

34
Q

Which standard IFN treats HBV?

35
Q

Protease inhibitors used for HCV, MOA?

A

Binds to HCV protease to inhibit viral replication

36
Q

Dasabuvir MOA and what is it used against?

A

Non-nuclodside polymerase inhibitor

HCV

37
Q

Which standard IFN treats both HBV and HCV?

38
Q

Dasabuvir AE?

A

Rash + puritis

39
Q

Which pegylated IFN treats HCV?

A

pegIFN a2a or pegIFN a2b

40
Q

What drugs are made up in the NS5A inhibitor class used against HCV?

A

End w/ “svir”

41
Q

NS5A AE?

42
Q

What is the MOA of Entecavir?

A

Inhibits HBV by:

  1. Prime DNA polymerase
  2. Reverse transcriptase
  3. DNA synthesis
43
Q

Which RX is superior to adefovir?

44
Q

Adefovir Dipivoxil is a nucleoside analog converted to __________ intracellularly

A

diphosphate

45
Q

Sofosobuvir MOA and what is it used against?

A

Nucleoside polymerase inhibitor

HCV

46
Q

What are the main drugs used in treating HCV?

A
  1. Ribavirin
  2. Interferon-alpha (no longer used)
  3. Protease inhibitors
  4. NS5B inhibitors
  5. NS5A inhibitors

Infectious Disease (32 decks)

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