Intro to Immunology (Soluble Factors + APR)

Question 1

Which of the following marks the pathogen for destruction by immune cells?

A. Complement
B. Cytokines
C. Chemokines
D. Defensins

Answer 1

A. Complement

Question 2

Which of the following affects the behavior of nearby cells by raising body temperature and activating the liver?

A. Complement
B. Cytokines
C. Chemokines
D. Defensins

Answer 2

B. Cytokines

Question 3

When cytokines are released, how do they raise the body temperature?

Answer 3

Use of pyrogens

Question 4

When cytokines are released, they activate the liver to produce what response?

Answer 4

Produces the acute phase response by limiting growth of pathogen + attracts phagocytes to the area

Question 5

Which of the following attracts cell with the appropriate receptor to leave the blood stream and enter the inflamed tissue?

A. Complement
B. Cytokines
C. Chemokines
D. Defensins

Answer 5

C. Chemokines

Question 6

Which of the following are small antimicrobial proteins made via circulating WBC and some tissue?

A. Complement
B. Cytokines
C. Chemokines
D. Defensins

Answer 6

D. Defensins

Question 7

How do Defensins rupture bacterial membrane?

Answer 7

Increase water influx into bacterial cell. Some move thru the bacterial cell

Question 8

What do macrophages and dendritic cells release to initiate the acute phase response?

A. Complement
B. Cytokines
C. Chemokines
D. Defensins

Answer 8

B. Cytokines

Question 9

TNF-alpha, IL-1Beta, and IL-6 are pyrogens (T/F)

Answer 9

True

Question 10

TNF-alpha, IL-1Beta, and IL-6 stimulate macrophage mobilization (T/F)

Answer 10

False, neutrophils

Question 11

TNF-alpha, IL-1Beta, and IL-6 act on liver hepatocytes (T/F)

Answer 11

True