Protein Synthesis Flashcards
simply a change in a gene
mutation
involve a change in a single base pair & thus a change in the corresponding mRNA
Point mutations
are detected by gene sequence determination. There is no change in the amino acid sequence.
Silent mutations
mutations arise from a base change that causes incorporation of a different amino acid in the encoded protein (ex. Hemoglobin and sickle-cell disease).
Missense
mutations arise from point mutations that result in the formation or loss of a termination codon. The resulting protein maybe truncated or “read through”.
Nonsense
Three reasons why proteins would be synthesized in the RER
- Secreted proteins
- Membrane proteins
- Lysosomal proteins
Free ribosomes proteins are
Cytosolic ribosomes
Nuclear proteins
Mitochondrial enzymes
Peroxisomal enzymes