Prostaglandins and Eicosanoids

Question 1

Eicosanoids are derived from?

Answer 1

Arachidonic acis

Question 2

Eicosanoid: vascular smooth muscle relaxation, protective effects on gastric mucosa, maintains PDA

Answer 2

PGE1

Question 3

Eicosanoid: vascular smooth muscle relaxation, maintains PDA, increases uterine tone

Answer 3

PGE2

Question 4

Eicosanoid: vascular smooth muscle relaxation,(peripheral,pulmonary, coronary)

Answer 4

PGI2

Question 5

Increases uterine tone, decreases IOP

Answer 5

PGF2a

Question 6

Activates EP receptors, causes increased HCO3 and mucus secretion in stomach, uterine contraction

Answer 6

Misoprostol

Question 7

Indicated for PUD ,prevention of nsaid induced gastric mucosal injury

Answer 7

Misoprostol

Question 8

SE: moebius sequence

Answer 8

Misoprostol

Question 9

Activates EP receptors , causes vascular smooth muscle relaxation and vasodilation; indicated for maintenance of PDA and erectile dysfunction

Answer 9

Alprostadil

Question 10

Eicosanoids include:

Answer 10

Leukotrienes, Prostacyclin, Prostaglandin, Thromboxane

Question 11

Eicosanoid family that is straight chain

Answer 11

Leukotrienes

Question 12

Prostaglandin E1 analogues

Answer 12

Misoprotol, alprostadil

Question 13

Prostaglandin E2 analog

Answer 13

Dinoprostone

Question 14

Prostaglandin F2a analog

Answer 14

Carboprost, latanoprost

Question 15

Prostaglandin I2 analog

Answer 15

Epoprostenol

Question 16

Eicosanoid: Low concentrations contract, higher concentration relax uterine and cervical smooth muscle

Answer 16

Dinoprostone

Question 17

Control of postpartum hemorrhage

Answer 17

Carboprost

Question 18

Pulmonary hypertension, reduces platelet aggregation in dialysis mahines

Answer 18

Epoprostenol

Question 19

Glacuoma

Answer 19

Latanoprost

Question 20

Permanent eye color change

Answer 20

Latanoproet