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Topnotch Pharmacology (Sept 2017) > Autonomics > Flashcards

Autonomics Flashcards

1
Q

Blocks ACh synthesis(choline acetyltransferase)

A

Hemicholium

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2
Q

Blocks storge of ACh

A

Vesamicol

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3
Q

Alter synaptobrevins to prevent release of Ach

A

Botulinum

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4
Q

Indirect acting cholinomimetics

A

Neostigmine, carbamates, organophosphates

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5
Q

Direct acting cholinomimetics include:

A

Betanechol, pilocarpine, nicotine

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6
Q

For bowel and bladder atony

A

Bethanechol( BBB)

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7
Q

Glaucoma, sjogren syndrome, sicca syndrome

A

Pilocarpine

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8
Q

Activates M3 receptors in ciliary muscles and salivary glands

A

Pilocarpine

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9
Q

Xerostomia, xerophthalmia, rheumatoid arthritis

A

Sjogren syndrome

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10
Q

Activates nicotinic Ach receptors

A

Nicotine/ varenicline

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11
Q

Used for smoking cessation

A

Varenecline

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12
Q

Mushroom poisoning

A

Inocybe and amanita muscaria

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13
Q

Indirect acting cholinomimetics

A

edrophonium, neostigmine, rivastigmine

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14
Q

Diagnosis of MG(Tensilon Test), cholinergic crisis vs myasthenic crisis

A

Endrophonium

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15
Q

Managment of MG, oglilvie syndrome, glaucoma

A

Neostigmine

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16
Q

Muscarinic effects of neostigmine is blocked by this drug

A

Atropine

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17
Q

Indirect acting cholinomimetic used for alzheimer’s

A

Rivastigmine

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18
Q

Signs and symptoms of organophosphate poisoning

A

DUMBBELS- diarrhea, urination, miosis, bronchospasm, bradycardia, excitation, lacrimation, sweating, salivation

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19
Q

Competitively blocks all muscarinic receptors

A

Atropine

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20
Q

Antidote for organophosphate poisoning, bradycardia, hypersalivation, mydriatic, cyclopegic

A

Atropine

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21
Q

Binds phophorus of organophosphate, breaks organophosphate bond with cholinesterase

A

Pralidoxime

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22
Q

Cholinoreceptor blockers

A

Atropine, benztropine,ipratropium, scopolamine

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23
Q

Competitevely blocks all muscarinic receptors , restores neurotransmittet balance in the basal ganglia

A

Benzotripine/ biperiden

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24
Q

Cholinergic antagonist used for parkinson’s disease

A

Benztropine/ parkinson’s disease

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25
Q

Muscarinic antagonists for parkinsonism

A

Try to park your benz, bip here ( muscarinic antagonist for parkinsonism)

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26
Q

Asthma, copd

A

Ipratropium

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27
Q

Competitively blocks all muscarinic receptors, antagonizes histamine and serotonin

A

Scoplamine

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28
Q

Used in motion sickness

A

Scopolamine

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29
Q

S/sx of atropine toxicity

A

Hot as a hare, dry as a bone, red as a beet, blind as a bat,mad as a hatter

30
Q

Ganglion blocker used for hypertension

A

Hexamethonium

31
Q

Only depolarizing neuromuscular blocker

A

Succinylcholine (kapag nakapag deposit ka, success yun)

32
Q

Inhibits hydroxylation of tyrosine to dopa

A

Metyrosine

33
Q

Inhibits vesicular transport of norepinephrine and dopamine

34
Q

Increases stores of NE and dopamine

35
Q

Inhibits release of NE and dopa

A

Guanethidine

36
Q

Promotes release of NE and dopa

A

Amphetamines and tyramine

37
Q

Inhibits termination of NE and dopa

A

Cocoaine and TCAs

38
Q

Activates a1,b1 and b2

39
Q

Sympathomimetics:

A

Epinephrine, norepinephrine, dopamine

40
Q

Activates a1,b1, and d1

41
Q

Dose of dopamine that causes vasodilation in the splanchnic and renal vascular beds

A

1-5 mcg/kg/min

42
Q

Dose of dopamine that increases renal blood flow , heart rat, cardiac contractility and b1 receptors

A

5-15 mcg/kg/min

43
Q

Vasoconstriction and increased blood pressure

A

> 15 mcg/kg/min

44
Q

Non selective activator of B adrenergic receptors used for asthma

A

Isoprotetenol

45
Q

Selective alpha1 agonist

A

Phenlyephrine, pseudoephedrine

46
Q

Selective alpha2 agonist

A

Clonidine, methyldopa, apraclonidine

47
Q

Selective Beta1 agonist

A

Dobutamine

48
Q

Selective B2 agonist

A

Albuterol/salbutamol

49
Q

Used in preeclampsia

A

Methyldopa

50
Q

A2 selective agent in glaucoma

A

Apraclonidine

51
Q

Used in cardiac stress testing

A

Dobutamine

52
Q

Drug of choice for acute asthma attack

A

Albuterol/salbutamol

53
Q

Nonselective alpha blockers:

A

Phenoxybenzamine, phentolamine

54
Q

Used for pheochromocytoma

A

Phenoxybenzamine

55
Q

Irreversible blocks a adrenergic receptors

A

Phenoxybenzamine

56
Q

Reversibly blocks a adrenergic receptors

A

Phentolamine

57
Q

Management for a1 agonist overdose and rebound hypertension

A

Phentolamine

58
Q

Selective a1 blockers

A

Prazosin, tamsulosin, terazosin

59
Q

Selectively blocks a1 adrenergic receptors- used for benign prostatic hyperplasia

A

Prazosin,tamsulosin

60
Q

Beta nonselective sympathomimetic

A

Isoproterenol

61
Q

Nonselective beta blocker

A

Propanolol

62
Q

Selective b blocker(b1)

63
Q

Blocks b1 and b2 receptors, blocks sympathetic effects on heart and BP, reduces renin releaae

A

Propanolol

64
Q

Used for performance anxiety

A

Propanolol

65
Q

Drugs with intrinsic sympathomimetic activity

A

Acebutolol, pindolol

66
Q

Nonselective beta blocker with the longest half life

67
Q

Selective b1 blocker

68
Q

Flow of aqueous humor

A

Ciliary body, posterior chamber, anterior chamber angle pupil anterior chamber, trabecular meshwork canal of shlemm uveoscleral veins

69
Q

Increases outflow through canal of schlemm

A

Latanoprost

70
Q

Increased outflow via uveosacral veins

A

Epinephrine

71
Q

Ciliary muscle contraction, opening of trabecular meshwork, increased outflow

A

Pilocarpine, physostigmine

Topnotch Pharmacology (Sept 2017) (38 decks)

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