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Topnotch Pharmacology (Sept 2017) > Antifungal > Flashcards

Antifungal Flashcards

1
Q

Sporothrix schenckii

A

Itraconazole or POTassium iodide(plant a rose in a pot)

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2
Q

Coccidiodes immitis

A

Amphotericn b/ itraconazole; fluco for meninitis

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3
Q

Histoplasma capsulatum

A

Amphotericin/ itraconazole; fluco for meningitis

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4
Q

Blastomyces dermatitidis

A

Itraconazole

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5
Q

Paracoccidioidea brasilensis

A

Itraconazole

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6
Q

Candida

A

Oropharyngeal and esophageal- nystagin swish and swallow; skin- clotrimazole; disseminated candidiasis- amphotericin B; chemoprophylaxis- fluconazolr

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7
Q

Cryptococcus neoformans

A

Ampho/ flucytosine; chemoproph: fluconazole

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8
Q

Aspergillus fumigatus

A

Amphotericin B

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9
Q

P jiroveci

A

TMP- SMX

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10
Q

Malassezia furfur

A

Miconazole

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11
Q

Polyene antifungal that binds to ergosterol forming artificial pores

A

Amphotericin B

Nystatin

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12
Q

Amphotericin B: Fungicidal or Fungistatic?

A

Fungicidal

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13
Q

Accumulates in fungal cells by the action of permease and converted to cytosine deaminase to 5-FU.

A

Flucytosine

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14
Q

A pyrimidine antimetabolite antifungal

A

Flucytosine

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15
Q

Inhibit fungal P450-dependent enzymes blocking ergosterol sysntesis

A

Azoles (Keto, Fluco, Itraco)

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16
Q

Antifungal with good CNS permeability

A

Fluconazole

17
Q

Inhibits B-glucan synthase decreasing fungal cell wall synthesis

A

Caspofungin

18
Q

Antifungal that accumulates in keratin. Contraindicated in porphyria

A

Griseofulvin and Terbinafine

19
Q

Interferes with microtubule function. Inhibits sysnthesis and polymerization of nucleic acids,

A

Griseofulvin

20
Q

Interfere with ergosterol synthesis by inhibiting fungal squalene oxidase.

A

Terbinafine

21
Q

DOC for pityriasis versicolor

A

Clotrimazole

Topnotch Pharmacology (Sept 2017) (38 decks)

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