Antivirals

Question 1

Drugs used for herpes

Answer 1

Acyclovir, ganciclovir, foscarnet

Question 2

Drugs for influenza

Answer 2

Amantadine, zanamivir

Question 3

Drugs for HBV and HCV

Answer 3

Inf-a, lamivudine, ribavirin

Question 4

Activated by thymidine kinase to formals that inhiit viral DNA polymerase

Answer 4

Acycolvir

Question 5

Inhibits viral DNA polymerase , causing chain termination

Answer 5

Ganciclovor

Question 6

Inhibits RNA polymerase, DNA polymerase and HIV reverse transcriptase. Binds to pyrophosphate binding site.

Answer 6

Foscarnet

Question 7

DOC for CMV retinits(?)

Answer 7

Cifodovir

Question 8

Antiviral that can cause hypocalcemia

Answer 8

Foscarnet

Question 9

Drugs for HIV

Answer 9

Indinavir, enduvirtide, maraviroc, zidovudine, delavirdine (nucleoside reverse transcriptase inhibitor, nnrti, protease inhibitor, fusion inhibitor, ccr5 receptor antagonist)

Question 10

Inhibits HIV transcriptase after phosphorylation by cellular enzymes

Answer 10

Zidovudine

Question 11

Inhibit reverse transcriptase. No phosphorylation required.

Answer 11

Delavirdine

Question 12

Inhibits viral protein processing

Answer 12

Indinavir

Question 13

Binds to gp41 subunit of viral envelope glycoprotein, preventing fusion of viral and cellular membranes

Answer 13

Enfuvirtide

Question 14

Blocks viral attachment via transmembrane chemokine receptor CCR5

Answer 14

Maraviroc

Question 15

Inhibit early step replication and prevent UNCOATING by binding yo M2 proton channels

Answer 15

Amantadine

Question 16

Inhibits neuraminidase. Decreases release of progeny virus.

Answer 16

Oseltamivir

Question 17

Degrades viral RNA via activation of host cell RNAase(ribonuclease)

Answer 17

Interferon a

Question 18

Inhibits HBV DNA polymerase

Answer 18

Lamivudine

Question 19

Inhibits guanosine triphosphate formation. Prevents capping of viral mRNA. Blocks RNA dependent RNA polymerase

Answer 19

Ribavirin