Drugs Used In Parkinsonism

Question 1

Parkinsonism is due to

Answer 1

Degeneration of dopaminergic neurons in substantia nigra

Question 2

Drug induced parkinsonism is due to

Answer 2

Typical antipsychotics, reserpine, MPTP(methylphenyltetrahydropyridine)

Question 3

Alternating periods of improved mobility and akinesia

Answer 3

On-Off phenomena

Question 4

deterioration of drug effect in betweem medication dosese

Answer 4

Wearing off phenomena

Question 5

Wearing off effect due to

Answer 5

destrucion of nigrostriatial neurons

Question 6

Primary drug for Parkison’s

Answer 6

Levodopa Carbidopa

Question 7

Carbidopa inhibits peripheral metabolism via

Answer 7

Dopa carboxylase

Question 8

Levodopa Carbidopa CI in

Answer 8

Psychosis

Question 9

Bromocriptine is partial agonist of

Answer 9

D2 receptors in brain

Question 10

Used for levodopa intolerance and hyperprolactinemia

Answer 10

Bromocriptine

Question 11

May cause erythromelalgia

Answer 11

Bromocriptine

Question 12

Partial agonist at D3 receptors

Answer 12

Pramipexole

Question 13

SE: Compulsive gambling, overeating

Answer 13

Pramipexole

Question 14

Also for restless leg syndrome

Answer 14

Pramipexole

Question 15

Partial agonist at D3 receptors. Antagonizes 5HT and alpha adrenoreceptors

Answer 15

Apomorphine

Question 16

Used for Off Periods

Answer 16

Apomorphine

Question 17

Also for alcoholism, Opiate addiction, Erectile dysfunction and Alzheimer’s

Answer 17

Apomorphine

Question 18

When giving Apomorphine what premedication is given

Answer 18

Trimethobenzamide

Question 19

MAO type B inhibitor, leades to decreased degredation of dopamine; Increases response to dopamine

Answer 19

Selegiline

Question 20

Serotonin syndrome when used with SSRI

Answer 20

Selegiline

Question 21

COMT inhibitor, thus blocks L dopa metabolism

Answer 21

Entacapone

Question 22

For Wearing Off phenomena

Answer 22

Entacapone

Question 23

Potentiates dopaminergic action, Influences synhtesis release or reuptake of dopamine at Adenosine 2A receptors

Answer 23

Amantadine

Question 24

Blue red lacy pattern at extremities

Answer 24

Livedo reticularis

Question 25

Decrease excitatatory actions of cholinergic neurons on cells in the striatum by blocking muscarinic receptors

Answer 25

Benztropine

Question 26

For extrapyramidal sx caused by antipsychotics

Answer 26

Benztropine

Question 27

Drugs used in Parkinsonism

Answer 27

Bromocriptine, Pramipexole, Apomorphine, Selegiline, Entacapone, Amantadine, Benztropine

Question 28

Parkinsonism is also known as

Answer 28

Paralysis agtans