Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Topnotch Pharmacology (Sept 2017) > Drugs Used In Parkinsonism > Flashcards

Drugs Used In Parkinsonism Flashcards

1
Q

Parkinsonism is due to

A

Degeneration of dopaminergic neurons in substantia nigra

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Drug induced parkinsonism is due to

A

Typical antipsychotics, reserpine, MPTP(methylphenyltetrahydropyridine)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Alternating periods of improved mobility and akinesia

A

On-Off phenomena

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

deterioration of drug effect in betweem medication dosese

A

Wearing off phenomena

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Wearing off effect due to

A

destrucion of nigrostriatial neurons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Primary drug for Parkison’s

A

Levodopa Carbidopa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Carbidopa inhibits peripheral metabolism via

A

Dopa carboxylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Levodopa Carbidopa CI in

A

Psychosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Bromocriptine is partial agonist of

A

D2 receptors in brain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Used for levodopa intolerance and hyperprolactinemia

A

Bromocriptine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

May cause erythromelalgia

A

Bromocriptine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Partial agonist at D3 receptors

A

Pramipexole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

SE: Compulsive gambling, overeating

A

Pramipexole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Also for restless leg syndrome

A

Pramipexole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Partial agonist at D3 receptors. Antagonizes 5HT and alpha adrenoreceptors

A

Apomorphine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Used for Off Periods

A

Apomorphine

17
Q

Also for alcoholism, Opiate addiction, Erectile dysfunction and Alzheimer’s

A

Apomorphine

18
Q

When giving Apomorphine what premedication is given

A

Trimethobenzamide

19
Q

MAO type B inhibitor, leades to decreased degredation of dopamine; Increases response to dopamine

A

Selegiline

20
Q

Serotonin syndrome when used with SSRI

A

Selegiline

21
Q

COMT inhibitor, thus blocks L dopa metabolism

A

Entacapone

22
Q

For Wearing Off phenomena

A

Entacapone

23
Q

Potentiates dopaminergic action, Influences synhtesis release or reuptake of dopamine at Adenosine 2A receptors

A

Amantadine

24
Q

Blue red lacy pattern at extremities

A

Livedo reticularis

25
Q

Decrease excitatatory actions of cholinergic neurons on cells in the striatum by blocking muscarinic receptors

A

Benztropine

26
Q

For extrapyramidal sx caused by antipsychotics

A

Benztropine

27
Q

Drugs used in Parkinsonism

A

Bromocriptine, Pramipexole, Apomorphine, Selegiline, Entacapone, Amantadine, Benztropine

28
Q

Parkinsonism is also known as

A

Paralysis agtans

Topnotch Pharmacology (Sept 2017) (38 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions