Problems in term neonate Flashcards

1
Q

Upper airway disorders present with?

A

Stridor

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2
Q

Upper airway disorders

A

Cleft lip/palate
Pierre Robin Sequence
Choanal atresia

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3
Q

Cleft lip/palate

A
1/1000 live births
Common craniofacial anomaly
Palate in isolation w/wo lip
Polygenic inheritance but family hx NB
Severity varies
MDT
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4
Q

Cleft lip/palate embryology

A

Fuses anterior to posterior (soft palate to hard palate)
8th week
Failure of fusion of medial + lateral nasal processes
Failure of fusion of palate and maxillary processes

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5
Q

Cleft lip management

A

3 month surgery or at birth

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6
Q

Cleft palate management

A

6 - 12 months surgery

Further surgery when older

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7
Q

Cleft lip/palate short term complications

A

Feeding difficulties

  • special nipples
  • dental plate
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8
Q

Cleft lip/palate long term complications

A

Recurrent OM with effusion - hearing impairment
Speech difficulties
Abnormal facial growth
Orthodontic problems

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9
Q

Pierre Robin Sequence

Inheritance

A

AR but some X linked with club foot and cardiac malformations reported

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10
Q

Pierre Robin Sequence

Embryology

A

7th and 11th week mandibular hypoplasia - micrognathia
Retroglossoptosis
Posterior palatal defect

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11
Q

Pierre Robin Sequence complications

A

Respiratory obstruction (hypoxia and cor pulmonale)

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12
Q

Pierre Robin Sequence management

A

Avoid tongue obstruction (nursing prone, CPAP via NPT)
NGT for feeding
Micrognathia improves over 1st 2 years
Surgery of posterior palate at 1 year

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13
Q

Choanal atresia

A

Bony/membranous obstruction between nasal cavity and nasopharynx

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14
Q

Newborn infants are ______ breathers

A

obligatory nose breathers

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15
Q

Choanal atresia

Clinical presentation

A

Respiratory distress + cyanosis

Obstruction relieved on crying or opening mouth

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16
Q

Choanal atresia management

A

Immediate: oral airway/tracheal tube via mouth
Definitive: surgical correction by ENT asap

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17
Q

Respiratory disorders

A
TTN
Meconium aspiration
Congenital diaohragmatic hernia
Pneumonia
Pneumothorax
RDS
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18
Q

Transient tachypnoea of newborn

A

Most common RDS cause in term infants
More common post C/S
Delay in lung liquid absorption
Birth stress hormone response -> fluid moves from alveolar to interstitial space
Lower circulating [catecholamine]
Alveolar fluid reabsorption via Na channels in lung epithelium
Settles within 1/2 days of life but low O2 requirement and tachypnea for several days

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19
Q

Transient tachypnoea of newborn management

A

Oxygen
NG feeding
CPAP

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20
Q

Meconium

A

1st intestinal discharge from newborn (viscous, dark-green, intestinal epithelial cells, lanugo, mucus, intestinal secretions)

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21
Q

Meconium is sterile

T/F

A

True

Does not contain bacteria

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22
Q

Meconium finding in amniotic fluid

A

Infants born at term/post-term

Rare prior to 34-36 weeks gestation

23
Q

Meconium aspiration

Influencing factors

A
Placental insuffiency
Hypoxia
Maternal HT
Preeclampsia
Oligohydramnios
Maternal drug abuse
24
Q

Meconium aspiration

Complications

A
Airway obstruction
Surfactant dysfunction
Chemical pneumonitis
Pneumothorax
PPHN
25
Meconium aspiration | Management
``` NO CPAP Prevent Mechanical ventilation Inotropes (systemic vasoconstrictors) Sildenafil Nitric oxide Poor cry - ABC No cry - suction then ABC ```
26
Congenital pneumonia | Risk factors
``` PROM Maternal fever/tachycardia Chorioamnionitis Maternal UTI/vaginitis hx Spontaneous preterm labour ```
27
Infants with RSD
``` Start on broad spectrum antibiotics until results known Blood culture CRP CBC LP ```
28
Congenital pneumonia | Most common pathogen
GBS | Tx penicillin, ventilation (if respiratory failure signs)
29
Congenital diaphragmatic hernia
Diaphragm defect - bowel herniates into thorax | Reduced foetal lung development -> pulmonary hypoplasia + PPHN
30
Congenital diaphragmatic hernia | Types
Bochdalek (left sided through posterolateral foramen) | Morgagni (central anterior)
31
Congenital diaphragmatic hernia | How to diagnose
Prenatal CXY imaging Clinically during resus
32
Congenital diaphragmatic hernia | Clinical signs
``` RDS Chest asymmetry Reduced air entry effected side Displaced apex beat Scaphoid abdomen ```
33
Congenital diaphragmatic hernia management
``` NO CPAP Intubate and ventilate from birth Maintain pH but allow permissive hypercapnia Avoid bag mask ventilation NG tube + apply suction Stabilise and support circulation Early PEN NO for PPHN/consider sildenafil Repair surgically once stable and PPHN resolving ```
34
Pneumothorax development
``` Spontaneous Secondary (CPAP, mechanical ventilation) ```
35
Pneumothorax clinical diagnosis
Unilateral decreased breath sounds Unilateral decreased chest movements Transillumination of the chest Confirmed by CXR
36
Pneumothorax management
ICD insertion
37
Persistent pulmonary hypertension of newborn
PH leads to R-L shunting across patent formane ovale and patent DA, intrapulmonary
38
Persistent pulmonary hypertension of newborn | Clinical presentation
Cyanosis (low O2) | Reduction between pre and post ductal saturations
39
Persistent pulmonary hypertension of newborn | Causes
``` Birth asphyxia MAS Sepsis Diaphragmatic hernia Occasionally primary disorder ```
40
Persistent pulmonary hypertension of newborn | Investigations
CXR - underlying cause/normal - pulmonary oligaemia ECG to exclude CHD
41
Persistent pulmonary hypertension of newborn | Management
Oxygen Optimize mechanical ventilation Circulatory support as required Consider surfactant therapy Pulmonary vasodilator –inhaled nitric oxide (NO) Oral/IV sildenafil may be considered Consider high‐frequency oscillatory ventilation (HFOV) Extracorporeal membrane oxygenation (ECMO) as rescue therapy for severe respiratory failure
42
Congenital cardiac lesions
Most common group of structural malformations in newborns
43
Congenital cardiac lesions presentation
Antenatal detection on ultrasound screening Detection of a heart murmur on newborn examination Heart failure – respiratory distress or shock Cyanosis Postnatal detection with oxygen saturation screening
44
Congenital cardiac lesions risk factors
``` Chromosomal disorders ( Down syndrome) Maternal diseases (DM, drugs, SLE) Congenital infections (Rubella) Multiple pregnancy Syndromes ( VACTERAL, TAR, CHARGE) ```
45
Acyanotic congenital cardiac disorders | Most common?
VSD
46
Acyanotic congenital cardiac disorders | Present w?
Shock OR heart failure and breathlessness
47
Acyanotic congenital cardiac disorders | Left-to-right shunting
VSD, ASD, AVSD, PDA ``` Heart Failure: Several weeks after birth Breathlessness Difficulty feeding Sweating on the forehead during feeds Tachypnoeaand tachycardia Hepatomegaly FTT Recurrent chest infections Gallop rhythm +/-murmur\ Cardiomegaly ```
48
Acyanotic congenital cardiac disorders | Obstructive (duct dependent lesion)
Aortic coarctation, pulmonary stenosis, hypoplastic left heart ``` Shock: Cold peripheries Weak or absent pulses Collapse Low cardiac output Hypotension ```
49
Cyanotic congenital cardiac lesions
Central vs peripheral <5g/dL hemoglobin look at tongue + mucous membranes
50
No respiratory cause of cyanosis
Cyanotic congenital heart defect
51
Cyanotic congenital cardiac lesions | Diagnosis
``` Hyperoxia test PaO2<110mmHg likely to be cyanotic heart disease CXR ECG w/wo doppler Cardiac catheterization ```
52
Enlarged heart border may be due to normal ___
thymus
53
Boot heart shape
Tetralogy of Fallot
54
Cyanotic congenital cardiac lesions management
Maintain ABC Provide ventilation if necessary Correct metabolic acidosis, hypoglycaemia, hypocalcemia If duct‐dependent defect suspected or confirmed: Give prostaglandin intravenously to keep the ductusarteriosus Patent (expect apnea after high‐dose prostaglandin) Do not give additional oxygen unless SaO2 falls below 75% (oxygen will make the duct more likely to close If in heart failure: high‐output failure (after first week of life) –fluid restriction (acute only), diuretics, ACE inhibitors, e.g. captopril low‐output failure/shock –inotropes, volume support; arrhythmias require specific treatment. Refer to pediatric cardiac center for expert advice, diagnostic imaging and management.