Prions Flashcards
1
Q
Prion diseases
A
transmissible spongiform encephalopathies
2
Q
Important characteristics of prions
A
long incubation time, gradual increase in sx severity, no host immune response, neuro-patho findings
3
Q
Infectious prion disease etiology
A
exposure to exogenous PRPsc from eating infected beef, cannibalism, or contaminated surgical instruments
4
Q
Inherited prion disease etiology
A
mutation in PrPc gene favors spontaneous misfolded protein structure
5
Q
Prion dz sxs
A
dementia, ataxia, myoclonic jerks, death
6
Q
Specified risk material associated with prion disease
A
lymphatic and neural tissue
