Prescribing in Pregnancy

Question 1

most drugs can cross the placenta, which drug doesn’t cross?

Answer 1

heparin

Question 2

what kind of drugs cross the placenta more quickly?

Answer 2

small, lipid soluble drugs

Question 3

what might absorption be affected by in pregnancy

Answer 3

morning sickness

Question 4

why does the volume of distribution change ?

Answer 4

increased fat stores and increased plasma volume

Question 5

increased liver metabolism of some drugs

Answer 5

y

Question 6

why is the elimination of renal drugs increased?

Answer 6

GFR is increased

Question 7

when do you need to be careful giving anti hypertensives in pregnancy?

Answer 7

2nd trimester

Question 8

when should folic acid be given in pregnancy

Answer 8

3 months prior and first 3 months of pregnancy

Question 9

frequent seizures during pregnancy are associated with lower verbal IQ, hypoxia, bradycardia, antenatal death, maternal death

Answer 9

y

Question 10

when should you try and avoid drugs in pregnancy if at all possible?

Answer 10

first trimester, risk of early miscarriage, period of greatest teratogenic risk

Question 11

epilepsy, what should be given

Answer 11

folic acid - 5mg per day. vitamin k at 34-36 weeks to prevent haemorrhagic disease of newborn

Question 12

what two drugs should you avoid?

Answer 12

phenytoin and valproate

Question 13

poor control of diabetes increases risk of congenital malformations and IUD

Answer 13

insulin is safe in pregnancy

Question 14

a diabetic woman is on sulphonyl ureas and becomes pregnant. what drug should she be put on?

Answer 14

insulin

Question 15

what class of drugs may inhibit metal growth in late pregnancy?

Answer 15

beta blockers

Question 16

best drug for nausea and vomiting?

Answer 16

cyclizine

Question 17

UTI?

Answer 17

amoxicillin/cefalen

Question 18

pain?

Answer 18

paracetamol

Question 19

heartburn

Answer 19

ant acids

Question 20

warfarin in early pregnancy - risk of ?

Answer 20

teratogenic

Question 21

late?

Answer 21

haemorrhage during delivery

Question 22

foremilk and hindmilk - which has higher fat content?

Answer 22

hindmilk

Question 23

which is more protein rich?

Answer 23

foremilk

Question 24

which drug can cause sucling difficulties?

Answer 24

phenyl barbitones

Question 25

which drugs cause drowsiness?

Answer 25

benzodiazapines

Question 26

which cause hypothyroidism

Answer 26

amiodarone

Question 27

bone marrow suppression?

Answer 27

cytotoxics

Question 28

suppression of lactation?

Answer 28

bromocriptine

Question 29

fetal alcohol syndrome

Answer 29

flat midline, short nose, low nasal bridge, thin upper lip

Question 30

what can phenytoin cause?

Answer 30

cleft palate and lip

Question 31

which drug can cause spina bifida and anencephaly

Answer 31

sodium valproate

Question 32

sstilbestisol can cause clear cell adenocarcinoma and vaginal adenocarcinoma

Answer 32

.