Prescribing in Pregnancy Flashcards
most drugs can cross the placenta, which drug doesn’t cross?
heparin
what kind of drugs cross the placenta more quickly?
small, lipid soluble drugs
what might absorption be affected by in pregnancy
morning sickness
why does the volume of distribution change ?
increased fat stores and increased plasma volume
increased liver metabolism of some drugs
y
why is the elimination of renal drugs increased?
GFR is increased
when do you need to be careful giving anti hypertensives in pregnancy?
2nd trimester
when should folic acid be given in pregnancy
3 months prior and first 3 months of pregnancy
frequent seizures during pregnancy are associated with lower verbal IQ, hypoxia, bradycardia, antenatal death, maternal death
y
when should you try and avoid drugs in pregnancy if at all possible?
first trimester, risk of early miscarriage, period of greatest teratogenic risk
epilepsy, what should be given
folic acid - 5mg per day. vitamin k at 34-36 weeks to prevent haemorrhagic disease of newborn
what two drugs should you avoid?
phenytoin and valproate
poor control of diabetes increases risk of congenital malformations and IUD
insulin is safe in pregnancy
a diabetic woman is on sulphonyl ureas and becomes pregnant. what drug should she be put on?
insulin
what class of drugs may inhibit metal growth in late pregnancy?
beta blockers
