Premature Ovarian Insufficiency

Question 1

What is premature ovarian insufficiency

Answer 1

menopause <40y

Question 2

causes of premature ovarian insufficiency

Answer 2

• idiopathic
• bilateral oophorectomy
• hysterectomy with preservation of ovaries has also been shown to advance the age of menopause
• radiotherapy/chemotherapy
• infection: e.g. mumps
• autoimmune disorders
• Resistant ovary syndrome (FSH receptor abnormalities)

Question 3

Clinical features of premature ovarian insufficiency

Answer 3

• hot flushes, night sweats
• infertility
• secondary amenorrhoea

Question 4

Descibe the hormone levels found in premature ovarian insufficiency

Answer 4

• raised FSH, LH levels
• low oestradiol

Question 5

Management of premature ovarian insufficiency

Answer 5

HRT or COCP until average menopausal age