Ovarian Ca

Question 1

What is the peak age of incidence of ovarian cancer?

Answer 1

60years

Question 2

What type of cancer are most ovarian cancer?

Answer 2

90% epithelial

(70-80% of cases = serous carcinomas)

Question 3

Which part of the ovary is being recognised as the most common site of tumour development?

Answer 3

distal end of the fallopian tube

Question 4

Risk factors for the development of ovarian cancer

Answer 4

FHx: BRCA1/BRCA2 mutations

More ovulations:
ie. early menarche, late menopause, nulliparity

Question 5

What clinical features can present with ovarian cancer?

Answer 5

abdominal distension and bloating
abdo/pelvic pain
urinary symptoms e.g. Urgency
early satiety
diarrhoea

Question 6

What tumour marker can be tested for if a woman is symptomatic?

Answer 6

CA125

Question 7

What other conditions can raise the CA125 level?

Answer 7

Endometriosis
menstruation
benign ovarian cysts

Question 8

What is the common treatment route for ovarian cancer?

Answer 8

Combination of surgery and platinum-based chemotherapy

Question 9

What percentage of women have advanced disease at presentation?

Answer 9

80%

All stage 5-year survival is 46%