Multiple Endocrine Neoplasia (MEN)

Question 1

What is the inheritance pattern in Multiple Endocrine Neoplasia (MEN)?

Answer 1

Autosomal dominant

Question 2

Flip for a tip to remember the features of each MEN Type

Answer 2

MEN Type I = 3Ps
- Pituitary tumour
- pancreatic tumour
- Parathyroid Hyperplasia

MEN Type IIa = 2Ps
- Parathyroid
- Phaeochromocytoma

MEN Type IIb = 1P
- Phaeochromocytoma

Question 3

What types of pancreatic tumours are seen in MEN I?

Answer 3

Isulinoma

Question 4

What other types of cancer can occur in MEN I?

Question 5

What types of pancreatic tumours are seen in MEN I?

Answer 5

Insulinoma

Question 6

What other types of cancer can occur in MEN I?

Answer 6

Gastrinoma (=>recurrent peptic ulceration)
Adrenal
Thyroid

Question 7

What type of thyroid cancer links MEN IIa and IIb

Answer 7

Medullary Thyroid cancer

Question 8

Describe some typical clinical features seen in MEN IIb

Answer 8

Marfanoid body habitus
Neuromas

Question 9

Genetic mutation seen in MEN I

Answer 9

MEN1 gene

Question 10

Genetic mutation seen in MEN IIa and IIb

Answer 10

RET oncogene

Question 11

How do most patients with MEN I present?

Answer 11

Hypercalcaemia as a result of hyperparathyroidism