Hyperlipidaemia Flashcards
What conditions cause predominantly hypertriglyceridaemia?
diabetes mellitus (types 1 and 2)
obesity
alcohol
chronic renal failure
liver disease
What drugs predominantly cause high triglycerides?
- thiazides
- non-selective beta-blockers
- unopposed oestrogen
What predominantly causes hypercholesterolaemia?
nephrotic syndrome
cholestasis
hypothyroidism
Who should receive a statin as Primary prevention?
10-year cardio risk >10%
T1DM
CKD with eGFR <60
Who should receive statins as secondary prevention?
ischaemic heart disease
stroke
peripheral arterial disease
What dose of atorvastatin is used for Primary vs Secondary prevention?
20mg - Primary Prevention
80mg - Secondary Prevention
When should you consider a diagnosis of familial hypercholesterolaemia?
Total cholesterol >7.5 mmol/L
FHx of premature coronary heart disease <60y
What is remnant hyperlipidaemia?
- Rare mixed hyperlipidaemia
- Raised cholesterol and triglyceride levels
- thought to be caused by impaired removal of intermediate density lipoprotein from the circulation by the liver
What is remnany hyperlipidemia also known as?
1) Fredrickson type III hyperlipidaemia
2) broad-beta disease
3) dysbetalipoproteinaemia
What genetic component is found in Remnant hyperlipidaemia?
Homozygous for apo-e2
Clinical features of remnant hyperlipidaemia
yellow palmar creases
palmer xanthomas
tuberous xanthomas
high risk of IHD/peripheral vascular disease
What is the first line treatment for remnant hyperlipidaemia?
fibrates
