Hyperuricaemia Flashcards
1
Q
2 mechanisms of hyperuricaemia
A
- increased cell turnover
- reduced renal excretion of uric acid.
2
Q
What conditions cause increased synthesis?
A
Lesch-Nyhan disease
myeloproliferative disorders
diet rich in purines
exercise
psoriasis
cytotoxics
3
Q
What can cause reduced excretion of uric acid?
A
drugs: low-dose aspirin, diuretics, pyrazinamide
pre-eclampsia
alcohol
renal failure
lead
