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Pharmacy > PK & PD > Flashcards

PK & PD Flashcards

1
Q

half life of warfarin

A

1 week

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2
Q

half life of Prozac (FLuxetine)

A

2-4 days

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3
Q

Half life of Plutonium:

A

Plutonium: 40 years (liver), 100 years (bone)

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4
Q

Half life of the following:

Lead, Mercury

A

Lead: 28-36 days

Mercury: 65 days

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5
Q

There are three major metabolites of cocaine:

A
  1. benzoylecgonine (BE) formed from spontaneous hydrolysis:poor blood-brain barrier penetration, potent vasoconstrictor in vitro
  2. ecgonine methyl ester (EME) formed from metabolism by plasma pseudocholinesterase:poor blood-brain barrier penetration, vasodilator, sedative, and anticonvulsant, and is protective against lethal doses of cocaine
  3. norcocaine formed from metabolism by the p450 system (N-demethylation)
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6
Q

Half life of Heroin:

A

2-6 minutes

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Pharmacy (27 decks)

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