Immunopharmacology

Question 1

Innate immunity

Answer 1

Innate immunity (non-specific): fast, first line defense. i.e. NK cells, Neutrophils,Eosino,Baso, macrophages. Antigen independent. (Skin, hair, mucous)

Question 2

Main functions of antibodies:

Answer 2

1. Neutralization: fights bacteria.
2. Punching holes of bacterial cell wall. activating complement system.
3. Opsonization:phagocytic cells

Question 3

Types of Ab:

Answer 3

1. IgA
2. IgD
3. IgM
4. IgG
5. IgE

Question 4

IgG

Answer 4

highest concentration and is the Most common
Detoxification of harmful substances.
It crosses placenta and helps the fetus immunity until complete formation of hi/her immune system.

Question 5

IgM

Answer 5

5 Y-shaped molecules.

First response to any microbial invasion in the body

Question 6

IgD

Answer 6

induction of Ab protection

Question 7

Type IV hypersensitivity reactions:

Answer 7

T Cell-Mediated (Delayed Hypersensitivity).

productions of cytokines.

Takes 48-72 hrs of longer.

SJS, TB, fungal infections

Question 8

Adaptive immunity (specific):

Answer 8

Remembers germs, seconds, Long term (96hrs), T&B lymphocytes, ab, Ag dependent. i.e.Swelling, Pus, Redness. (synthesis of antibodies)

Question 9

Type III hypersensitivity reactions:

Answer 9

Immune Complex Reaction.

Ab-Ag complex forming

SLE, serum sickness, Leprosy

Question 10

IgA

Answer 10

Dimer shaped (2 dimer fused together)

-mucousal tissues

Present in breast milk & protect GIT of neonates from pathogens

Question 11

Type I hypersensitivity reactions:

Answer 11

Type I: Immediate Hypersensitivity (Anaphylactic Reaction)

Release of histamine, Serotonin, leukotrienes, Bradykinin, and prostaglandins

Question 12

IgE

Answer 12

Protection against parasites.

Primarily involved in Allergy !!!

Question 13

Type II hypersensitivity reactions:

Answer 13

IgG,IgM, 
Cytotoxic Reaction (Antibody-dependent) 

e.g.: Hemolytic anemia, Rh incompatibility, blood transfusion reactions.