Hematology Flashcards
Early graying of the hair,
Burning sensation in the tongue
Loss of proprioception
Are common signs of which anemia?
vitamin B-12 deficiency Anemia
Cheilosis (cracked lips) is associated with
Folate deficiency
a stage in RBC development directly before the mature RBC:
Reticulocyte
Red blood cells are produced in the …………….
bone marrow
Basophilic stippling commonly observed in ………….. poisoning
Lead
Diamond Blackfan anemia
An autosomal dominant genetic disorder caused by genetic mutations affecting ribosome synthesis thus, leading to activation of the tumor protein p53 (TP53). The erythropoietin level is consistently elevated in DBA because of ineffective erythropoiesis.
A mutation in the gene encoding ribosomal protein 19 (RPS19)
DBA is presented as:
normochromic (usually macrocytic) anemia
reticulocytopenia
markedly decreased or absent erythroid precursors
Congenital malformations
Bilirubin synthesis:
Heme —— via: Heme oxygenase—> Biliverdin ——– via: biliverdin reductase——-> bilirubin.
The direct antiglobulin test (DAT; direct Coombs test) is performed by adding …………………………. to patient RBCs.
anti-human globulin
The indirect antiglobulin test (IAT; indirect Coombs test) is performed by adding …………………………. to test RBCs followed by the addition of ………………………..
patient plasma to test RBCs
followed by:
anti-human globulin
Stomatocytosis characterized by:
mouth shaped area of central pallor in RBCs seen in peripheral blood smear
Spherocytes observed in:
small, dark, dense hyperchromic red cells without central pallor.
Present in hereditary spherocytosis or autoimmune hemolytic anemia.
presence of schistocytes indicates:
helmet shaped cells
microangiopathic hemolytic anemia (MAHA)
Pernicious Anemia
a form of megaloplastic anemia due to antibodies against intrinsic factor in the parietal cells of the stomach.
