Pick 6 Review Flashcards
ativan drug class
anticonvulsant/sedative/hypnotic/benzodiazepine
ativan indications
major motor seizures, premed for cardioversion, acute anxiety
ativan contraindications
hypersensitivity
ativan SE
hypotension, drowsiness, HA, amnesia, respiratory depression, blurred vision, N+V
ativan pedi dose
0.05 mg/kg
ativan precautions
have benzo antagonist available
ativan interactions
additive effects with other CNS depressants and alcohol
versed drug class
benzodiazepine/anticonvulsant/sedative/hypnotic
versed moa
positive allosteric modulator for GABA receptors, hyperpolarizes cells by increasing Cl- concentration
versed indications
pre med for cardioversion, post-intubation sedation, seizure
versed contraindications
narrow-angle glaucoma, shock, depressed vitals, alcoholic coma
versed side effects
laryngospasm, bronchospasm, dyspnea, respiratory depression and arrest, drowsiness, amnesia, AMS, tachycardia, bradycardia, PVC’s, retching
versed pedi dose
0.2mg/kg max of 10mg
versed precautions
have resuscitative equipment available, more potent than other benzos, have benzo antagonist available
versed interactions
additive effects with other CNS depressants and alcohol
albuterol moa
b2 agonist causes bronchodilation
albuterol contraindications
hypersensitivity, symptomatic tachycardia
albuterol SE
anxiety, HA, palpitations, sweating, dizziness, nervousness, tremor, HTN, arrhythmias, chest pain, N+V
albuterol precautions
monitor vitals and EKG; caution with heart disease or HTN, check lungs before and after
albuterol interactions
SE increased with other sympathetic agonists, beta blockers blunt effects, MAOI’s and TCA’s may potentiate cardiovascular effects
solu-medrol MOA
upregulates genes that produce inhibit inflammatory response - is an immunosuppressant
solu-medrol onset
2-6 hrs
solu-medrol peak
4-8 days
solu-medrol duration
1-5 weeks
solu-medrol indicaitons
anaphylaxis,hives; asthma, copd; spinal cord injury
solu-medrol contraindications
none
solu-medrol SE
fluid retention, CHF, HTN, abd. distention, vertigo, HA, nausea, malaise, hiccups
solu-medrol spinal cord injury
30mg/kg iv over 15 min, maintenance 5.4 mg/kg/hr for 24-48 hrs
solu-medrol precautions
one dose prehospitally, can prolong wound healing, suppression of adrenocortical steroids
solu-medrol interactions
lasix and thiazide diuretics increase K+ loss; decreased effect with phenytoin, phenobarbital, rifampin
mag sulfate drug class
electrolyte/antidysrhythmic/mineral
mag sulfate moa
physiological Ca2+ channel blocker causes CNS depression and smooth muscle relaxation
mag indications
asthma/bronchospasm; severe refractory VF or pulseless VT, torsades; post MI prophylaxis of dysrhythmias; eclampsia, pre-term labor
mag contraindications
3rd degree heart block, shock, severe hypertension, impaired renal function, hypocalcemia
mag SE
flushing, sweating, bradycardia, decreased deep tendon reflexes, drowsiness, respiratory depression, dysrhythmias, hypotension, hypothermia, itching, rash
mag adult asthma dose
2g in 100cc infused over 10 min
mag vt, vf, torsades no pulse adult dose
2g over 1-2 min
mag vt/torsades with pulse adult dose
1-2g in 50-100cc over 5-60 min
mag eclampsia dose
2-4g over 25 min
mag pedi asthma dose
25-50mg/kg infused over 15-30 min
mag pedi vt no pulse dose
25-50mg/kg
mag pedi vt with pulse dose
25-50 mg/kg over 10-20 min
mag precautions
watch for respiratory depression, have cacl2 available if OD
mag interactions
cardiac conduction abnormalities with digitalis
epi moa
a1 agonist causes peripheral vasoconstriction (increases SVT and BP); b2 agonist causes positive inotropy, chronotropy, dromotropy; b2 agonist causes bronchodilation; blocks destruction of MAST cells in anaphylaxis
epi indications
cardiac arrest; anaphylaxis/severe asthma; symptomatic bradycardia/hypotension
epi contraindications
HTN and tachydysrhythmias, caution with pregnancy and CAD
epi SE
anxiety, dysrhythmias, tremulousness, dizziness, N+V, increased myocardial oxygen demand
epi adult cardiac arrest dose
.5-1mg 1:10,000 q3-5 min
epi pedi cardiac arrest dose
.01mg/kg 1:10,000 q 3-5 min
epi bradycardia/hypotension adult dose
2-10 mcg/min
epi adult anaphylaxis dose
.3-.5mg IM 1:1000, then .1mg 1:10,000 over 3 min
epi pedi anaphylaxis dose
.01mg/kg 1:1000 then .01mg/kg 1:10,000 max dose .3mg
epi precautions
protect from light
epi interactions
inactivated by alkaline solutions, effect intensified by antidepressants, reacts with cacl2 and nahco3 to form ppt in tubing
nitroglycerin trade
nitrostat
nitrostat generic
nitroglycerin
nitro drug class
nitrate/vasodilator
nitro moa
converted to NO, activates GTP to cGMP +2pi activates cascade that reduces intracellular Ca2+ causing VSMC relaxation, decreasing cardiac preload and afterload
nitro indications
angina, CHF/pulmonary edema
nitro contraindications
shock, ICP, children under 12, ED drugs w/in last 48 hrs
nitro SE
HA, dizziness, weakness, tachycardia, mg SL hypotension, rash, dry mouth, N+V
nitro adult dose
0.4mg SL q3-5min until BP drops or pain relief (max 3x25min)
nitro precautions
monitor vitals, expect HA, do 12 lead prior, don’t use w/ R sided MI
nitro drug interactions
orthostatic hypotension with b-blockers, severe hypotension with alcohol
zofran drug class
antiemetic
zofran moa
serotonin R antagonist, especially at the vagal nerve
zofran indications
nausea/vomiting
zofran contraindications
hypersensitivity
zofran SE
HA, dizziness, tachycardia, chest pain, constipation, diarrhea, dry mouth, prolonged QT
zofran adult dose
4mg iv
zofran pedi dose
0.1mg/kg iv
zofran precaution
lower risk of sedation and dystonia than other antiemetics
zofran interactions
affects clearance and half-life with inducers and inhibitors of cytochrome p-450 enzymes
benadryl drug class
antihistamine
benadryl moa
competitive h1/h2 antagonist, blocks histamine release, inhibits reuptake and storage of dopamine leading to reduction of bronchoconstriction, vasodilation, increased vascular permeability
benadryl indications
allergic rx; anaphylaxis; dystonia
benadryl contraindications
hypersensitivity; asthma; nursing mothers
benadryl SE
sedation, dries bronchial secretions, blurred vision, HA, palpitations, dizziness, drowsiness, fatigue, euphoria
benadryl precautions
caution with severe liver disease, asthma, narrow angle glaucoma, BPH; may cause hypotension
benadryl interactions
potentiates sedative effects of alcohol, benzos, narcotics, other anti-HTN’s
benadryl contraindications
hypersensitivity; asthma; nursing mothers
benadryl SE
sedation, dries bronchial secretions, blurred vision, HA, palpitations, dizziness, drowsiness, fatigue, euphoria
adenosine drug class
class v antidysrhythmic/ nucleoside
adeonise moa
adenosine R agonist, slows AV conduction
adenosine indications
SVT; wide complex tachycardia
adenosine contraindications
2/3rd degree blocks; chemical induced SVT’s; caution with asthma, bronchospasm, unstable angine; torsades
adenosine SE
facial flushing, HA, chest pain, dizziness
adenosine pedi dose
1st dose 0.1mg/kg (max 6); 2nd dose 0.2 mg/kg (max 12) all followed by flush
adenosine precautions
print a strip as you’re pushing it; give in AC or higher
adenosine interactions
double the dose with methylxanthines; halve the dose with carbamazepines
amiodarone drug class
antidysrhythmic
amiodarone moa
class III antidysrhythmic/ K+ channel blocker prolongs cardiac AP and refractory period; has properties of Na+/Ca2+ channel blocker
amiodarone indications
VF and VT; wide complex tachycardia
amiodarone contraindications
cardiogenic shock, sinus node dysfunction, symptomatic bradycardia, 2nd/3rd degree blocks
amiodarone SE
hypotension, bradycardia, dyspnea, cough, dizziness, prolonged PR, QRS, QT intervals, increased ventricular beats
amiodarone VF/pulseless VT dose
300mg, repeat 150mg q3-5
amiodarone VF/ VT with a pulse dose
150mg over 10 min
amiodarone maintenance dose
1mg/min first 6 hrs, then 0.5mg/min
amiodarone VF/pulselss VT pedi dose
5mg/kg, max 300mg, max total dose 15 mg/kg