Drug Quiz 5 Flashcards

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1
Q

aspirin drug class

A

platelet aggregation inhibitor/anti-inflammatory

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2
Q

aspirin MOA

A

blocks formaton of thromboxane A2 prevents platelet aggregation; cox inhibitor, inhibits prostaglandin synthesis

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3
Q

aspirin onset of action

A

5-30 min

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4
Q

aspirin peak effects

A

15-120 min

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5
Q

aspirin duration of effect

A

1-4 hrs

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6
Q

aspirin half life

A

15-20 min

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7
Q

aspirin indications

A

chest pain suggestion of ami/acs

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8
Q

aspirin contraindications

A

hypersensitivity, active ulcer, asthma

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9
Q

aspirin side effects

A

gi bleeding, wheezing, n+v, heartburn

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10
Q

aspirin adult dose

A

160-325mg

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11
Q

aspirin pedi dose

A

not for pedi

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12
Q

aspirin precautions

A

can cause gi upset/bleeding

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13
Q

aspirin interactions

A

with other anti-inflammatories cause increased side effects; with antacid decreased absorption

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14
Q

morphine drug class

A

narcotic analgesic

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15
Q

morphine MOA

A

opiate R agonist, causes CNS depression, decreases preload and myocardial oxygen demand

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16
Q

morphine onset of action

A

immediate iv, 15-30 min im

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17
Q

morphine peak effects

A

20 min iv; 30-60 im

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18
Q

morphine duration of effect

A

2-7 hrs

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19
Q

morphine half life

A

1-7 hrs

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20
Q

morphine indications

A

severe pain, pulmonary edema

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21
Q

morphine contraindications

A

hypovolemia/hypotension; AMS; hypersensitivity; COPD/ compromised respiratory status

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22
Q

morphine side effects

A

nausea/vomitting, constricted pupils, AMS, respiratory depression

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23
Q

morphine adult dose

A

2-10mg iv initial, then 2mg q3-5

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24
Q

morphine pedi dose

A

0.1mg/kg iv

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25
Q

morphine precautions

A

respiratory depression, have narcan available

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26
Q

morhine interactions

A

additive effects with antihistamines, antiemetics, sedatives, hypnotics, barbituates, alcohol

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27
Q

ondansetron trade name

A

zofran

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28
Q

zofran generic name

A

ondansetron

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29
Q

zofran drug class

A

anti-emetic

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30
Q

zofran MOA

A

serotinin R antagonist, especially at vagal nerve terminals

31
Q

zofran onset of action

A

10-30 min

32
Q

zofran peak effects

A

unknown

33
Q

zofran duration of effects

A

unknown

34
Q

zofran half life

A

4 hrs

35
Q

zofran indications

A

nausea/vomitting

36
Q

zofran contraindications

A

hypersensitivity

37
Q

zofran side effects

A

prolonged QT interval, HA, dizziness, tachycardia

38
Q

zofran adult dose

A

4mg iv over 2-5 min

39
Q

zofran pedi dose

A

0.1 mg/kg iv over 2-5 min

40
Q

zofran precautions

A

lower risk of sedation and dystonia than other antiemetics

41
Q

zofran drug interactions

A

may effect clearance and half life with inducers and inhibitors of cytochrome p-450 enzymes

42
Q

nitro trade name

A

nitrostat

43
Q

nitro MOA

A

pro drug converted to nitric oxide, activates conversion of GTP to cGMP + 2Pi in VSMC, reduces intracellular Ca2+ causing VSMC relaxation, decreasing preload and afterload

44
Q

nitro onset of action

A

1-3 min SL, 30 min topical

45
Q

nitro peak effects

A

5-10 min SL, varies topical

46
Q

nitro duration of effect

A

20-30 min SL, 3-6 hrs topical

47
Q

nitro half life

A

1-4 min

48
Q

nitro indications

A

chest pain of cardiac origin, acute pulmonary edema/CHF

49
Q

nitro contraindications

A

systolic<100; ICP, children under 12, ED drugs w/in 48 hrs

50
Q

nitro side effects

A

HA, dizziness, hypotension, tachycardia

51
Q

nitro spray dose

A

0.4mg SL q3-5 (max 3x25min)

52
Q

nitro paste dose

A

0.5-1 inch

53
Q

nitro tablet dose

A

0.4mg SL

54
Q

nitro pedi dose

A

not for kids

55
Q

nitro precautions

A

monitor vitals, 12 lead prior to administration, caution w/ R sided MI

56
Q

nitro interactions

A

orthostatic hypotension w/ b-blockers, severe hypotension w/ alcohol

57
Q

epinephrine trade name

A

adrenalin, epipen

58
Q

epi drug class

A

sympathomimetic, catecholamine

59
Q

epi moa

A

a1 agonist causing peripheral vasoconstriction; b1 agonist causing positive inotropy, chronotropy, dromotropy; b2 agonist causing bronchodilation; blocks destruction of MAST cells

60
Q

epi onset of action

A

<2 min IV, 3-10 min IM

61
Q

epi peak effects

A

<5 min IV, 20 min IM

62
Q

epi duration of effect

A

5-10 min IV, 20-30 min IM

63
Q

epi half-life

A

5 min

64
Q

epi indications

A

cardiac arrest, anaphylaxis, symptomatic bradycardia

65
Q

epi contraindications

A

HTN and tachydysrhythmias, caution with pregnancy and CAD

66
Q

epi side effects

A

anxiety, HA, dysrhythmias, tremulousness

67
Q

epi adult cardiac arrest dose

A

0.5-1mg iv [1:10,000] q3-5

68
Q

epi pedi cardiac arrest dose

A

0.01mg/kg iv [1:10,000] q3-5

69
Q

epi bradycardia/hypotension dose

A

2-10 mcg/min

70
Q

epi anaphylaxis adult dose

A

0.3-0.5mg im [1:1,000], then 0.1mg [1:10,000] iv over 3 min

71
Q

epi pedi anaphylaxis dose

A

0.01mg/kg im [1:1,000], then 0.01mg/kg [1:10,000 iv (max of 0.3mg)

72
Q

epi precautions

A

protect from light

73
Q

epi drug interactions

A

inactivated by alkalinity, effects intensified with antidepressants, forms ppt with CaCl2 and NaHCO3