Drug Quiz 9 Flashcards

albuterol, epinephrine, solumedrol, amyl nitrate, activated charcoal, benadryl

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1
Q

albuterol sulfate trade name

A

proventil hfa, proair hfa

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2
Q

proventil and proair hfa generic name

A

albuterol sulfate

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3
Q

albuterol drug class

A

sympathetomimetic

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4
Q

albuterol MOA

A

b2 agonist, bronchodilation

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5
Q

albuterol onset

A

5-15 min

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6
Q

albuterol peak

A

1-1.5 hrs

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7
Q

albuterol duration

A

3-6 hrs

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8
Q

albuterol half life

A

<3 hrs

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9
Q

albuterol indications

A

asthma, copd bronchospasms

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10
Q

albuterol contraindications

A

symptomatic tachycardia, hypersensitivity

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11
Q

albuterol SE

A

anxiety, nervousness, HTN, chest pain

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12
Q

albuterol MDI dose

A

90 mcg 1 or 2 sprays

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13
Q

albuterol adult dose

A

2.5 mg in 2.5 ml NS over 5-15 min

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14
Q

albuterol pedi dose

A

same as adult

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15
Q

albuterol precautions

A

monitor BP, pulse, EKG, LS; use caution with heart disease and HTN

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16
Q

albuterol interactions

A

SE may increase with other sympathomimetics; B blockers may blunt effects; MAOI and TCA may potentiate cardiovascular effects

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17
Q

methylprednisolone trade name

A

solu-medrol

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18
Q

solu-medrol generic

A

methylprednisolone

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19
Q

solu-medrol drug class

A

corticosteroid

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20
Q

solumedrol MOA

A

upregulates synthesis of proteins/enzymes that inhibit inflammatory agents (like cytokines, interleukin, interferon)

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21
Q

solu-medrol onset

A

2-6 hrs

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22
Q

solu-medrol peak

A

4-8 days

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23
Q

solu-medrol duration

A

1-5 weeks

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24
Q

solu-medrol half life

A

3.5 hours

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25
Q

solu-medrol indications

A

anaphylaxis, asthma, copd, spinal cord injury

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26
Q

solu-medrol contraindications

A

none ems

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27
Q

solu-medrol SE

A

fluid retention, CHF, HTN, malaise

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28
Q

solu-medrol adult asthma/anaphylaxis dose

A

125-250 mg IV

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29
Q

solu-medrol adult spinal cord injury

A

30mg/kg over 15 min, maintenance 5.4 mg/kg/hr for 24-48 hrs

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30
Q

solu-medrol pedi asthma dose

A

2mg/kg max 80mg

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31
Q

solu-medrol precautions

A

one dose prehospitally, can prolong wound healing, suppression of adrenocortical steroids

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32
Q

solu-medrol interactions

A

lasix and thiazide diuretics increase K loss, decreased effect with phenytoin, phenobarbital, and rifampin

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33
Q

epinephrine trade name

A

adrenalin, epipen

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34
Q

adrenalin, epipen generic

A

epinephrine

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35
Q

epinephrine class

A

catecholamine

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36
Q

epinephrine moa

A

a1 agonist (peripheral vasoconstriction, increases SVR and BP); b1 agonist (positive inotropy, chronotropy, dromotropy); b2 agonist (bronchodilation); blocks destruction of MAST cells

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37
Q

epinephrine onset

A

<2 min iv, 3-10 im

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38
Q

epinephrine peak

A

<5 min iv, 20 im

39
Q

epinephrine duration

A

5-10 min iv, 20-30 im

40
Q

epinephrine half-life

A

5 min iv

41
Q

epi indications

A

CA, anaphylaxis, symptomatic bradycarida/hypotension

42
Q

epi contraindications

A

HTN, tachydysrhythmias, caution with pregnancy and CAD

43
Q

epi SE

A

anxiety, dysrhythmias, dizziness, increased myocardial O2 demand

44
Q

epi adult CA dose

A

0.5-1mg (1:10,000) q 3-5

45
Q

epi pedi CA dose

A

0.01mg/kg (1:10,000) q3-5

46
Q

epi bradycardia/hypotension dose

A

2-10 mcg/min

47
Q

epi anaphylaxis adult dose

A

0.3-0.5 mg IM (1:1,000) then 0.1mg (1:10,000) over 3 min

48
Q

epi anaphylaxis pedi dose

A

0.01mg/kg IM (1:1,000), then 0.01 mg/kg (1:10,000) max of .3mg over 3 min

49
Q

epi precautions

A

protect from light

50
Q

epi interactions

A

deactivated by alkaline, intensified by antidepressants, forms PPT with CaCl2 and NaHCO3

51
Q

diphenhydramine trade

A

benadryl

52
Q

benadryl generic

A

diphenhydramine

53
Q

benadryl drug class

A

antihistamine

54
Q

benadryl moa

A

blocks histamine release, suppresses central cholinergic activity and inhibits reuptake/storage of DA, leads to reduction of bronchoconstriction, vasodilation, increased vascular permeability

55
Q

benadryl onset

A

10-15 iv, 15-30 po

56
Q

benadryl peak

A

1-4 hrs

57
Q

benadryl duration

A

6-8 hrs

58
Q

benadryl half life

A

1-4 hrs

59
Q

benadryl indications

A

allergic rx, anaphylaxis, dystonia

60
Q

benadryl contraindications

A

hypersensitivity, asthma, nursing mothers

61
Q

benadryl SE

A

sedation, dizzy, drowsy, fatigue

62
Q

benadryl adult dose

A

25-50 iv, im, po

63
Q

benadryl pedi dose

A

1mg/kg iv, im, po

64
Q

benadryl precautions

A

caution with liver disease, asthma, narrow angle glaucoma, bph; may cause hypotension

65
Q

benadryl interactions

A

potentiates sedate effects of alcohol, benzos, narcotics, TCA’s, MAOI’s, lasix

66
Q

amyl nitrate class

A

antidote/nitrate

67
Q

amyl nitrate moa

A

vasodilator; oxidizes hemoglobin to methemoglobin, combines with cyanide to form cyanomethemoglobin which can be degraded

68
Q

amyl nitrate onset

A

10-30 sec

69
Q

amyl nitrate peak

A

30 sec

70
Q

amyl nitrate duration

A

3-5 min

71
Q

amyl nitrate half-life

A

n/a

72
Q

amyl nitrate indications

A

cyanide poisoning

73
Q

amyl nitrate contraindications

A

none

74
Q

amyl nitrate SE

A

headache, dizzy, syncope, hypotension

75
Q

amyl nitrate adult dose

A

0.3ml inhaled over 15-30 sec, q1 min

76
Q

amyl nitrate pedi dose

A

0.3ml inhaled over 15-30 sec, q1 min

77
Q

amyl nitrate precautions

A

may be drug of abuse, smells like sweaty socks, ensure Pt is sitting

78
Q

amyl nitrate interactions

A

hypotension potentiated by antihypertensives, b blockers, phenothiazines

79
Q

activated charcoal trade

A

actidose, liqui-char

80
Q

actidose, liqui-char generic

A

activated charcoal

81
Q

charcoal class

A

antidote

82
Q

charcoal moa

A

binds toxic substances, inhibiiting GI absorption, excreted in feces

83
Q

charcoal onset

A

immediate

84
Q

charcoal peak

A

unknown

85
Q

charcoal duration

A

unknown

86
Q

charcoal half-life

A

unknown

87
Q

charcoal indications

A

acute toxic ingestion

88
Q

charcoal contraindications

A

cyanide, caustic or petroleum based agents

89
Q

charcoal SE

A

vomitting, diarrhea, cramping, bloating

90
Q

charcoal adult dose

A

1g/kg (30-100g) PO

91
Q

charcoal pedi dose

A

1-2g/kg PO

92
Q

charcoal precautions

A

give within 30 minutes of overdose, give po to conscious Pt and with NG tube for unconscious Pt

93
Q

charcoal interactions

A

food or other meds administered concurrently will decrease absorptive capacity of charcoal