Physio 4 Diseases Flashcards
autosomal dominant disorder
cause tumors in multiple endocrine tissues
Type 1, Type 2A & 2B
Multiple Endocrine Neoplasia (MEN)
Pituitary,
pancreatic
parathyroid
MEN gene
MEN Type 1
medullary thyroid cancer
pheochromocytoma
parathyroid hyperplasia
-REC gene
MEN Type 2A
Medullary thyroid cancer
pheochromocytoma
neuronal mucosa
-REC gene
MEN Type 2B
MEN type 2
-protooncotic gene mutation
-prophylactic thyroidectomy
REC mutation
overproduction of aldosterone
Conn’s Syndrome
- headache
- ascites
- nephrotic syndrome
- diuretic use
- hypokalemia causing muscle weakness
- nocturnal polyuria
- hand cramping
Conn’s Syndrome Symptoms
hypersecretion of cortisol
Cushing Syndrome
Truncal obesity with thin extremities Moonface Buffalo hump Supraclavicular fat pads Generalized muscle wasting and weakness Fragile skin that easily bruises Reddish-purple striae on the abdomen and upper thighs Hirsutism Hypertension ↑Na ↓Ca2+ and K+
Cushing syndrome symptoms
hyposecretion of adrenal cortex
Addison’s Disease
- bronze skin
- lethargy, muscle weakness
- weight loss
- postural hypotension
- dehydration
- emotional distrubances
Addison’s Disease symptoms
tumor of the adrenal medulla
-overproduction of catecholamines
Phenochromocytoma
Persistent Hypertension Increased Heart Rate, palpitations Weight loss Hyperglycemia, glucosuria, polyuria Pallor, tremor, nervousness Weakness, visual disturbance Pain Histamine test VMA test
phenochromocytoma Symptoms
adrenal gland failure due to bleeding into the adrenal gland
-often due to meningococcal infection
Waterhouse-Friderichsen syndrome
excessive activity of the thyroid gland
-graves disease
Hyperthyroidism
