Pharmacology principles

Question 1

The hypothetical volume into which the administered drug must be uniformly distributed to have its effect

Answer 1

Volume of distribution (amount given mg/plasma concentration mg/L)

Question 2

Drugs with a low Vd (3-5 liters) likely

Answer 2

Have large molecular weight, are bound extensively to plasma proteins or are highly charged (hydrophilic)

Question 3

Drugs with Vd ~ 14-16L are likely

Answer 3

Small but hydrophilic

Question 4

Drugs with very large Vd (~35-40L) are likely

Answer 4

small MW and uncharged (liphophilic)

Question 5

Which drugs have the greatest volume of distribution

Answer 5

Drugs that can cross the plasma into interstitium (small and hydrophobic)

Question 6

List 5 CYP450 inducers

Answer 6

Carbamazepine, Phenobarbital, Phenytoin, Rifampin, Griseofulvin

Question 7

LList 7 CYP450 inhibitors

Answer 7

Cimetidine, Ciprofloxacin, Erythromycin, Azole antifungals, Grapefruit juice, Isoniazid, Ritonavir (protease inhibitors)

Question 8

A drug that undergoes hepatic metabolism should have which property?

Answer 8

High lipophilicity

Question 9

Drug that is excreted in urine will have which properties

Answer 9

Low lipophilicity, low Vd

Question 10

How are drugs with low rate of redistribution eliminated?

Answer 10

Kidneys