Chemotherapy

Question 1

What are the side effects of Vincristine?

Answer 1

Nerutoxicity

Question 2

What are the side effects of bleomycin?

Answer 2

Pulmonary fibrosis and flagellate skin discoloration

Question 3

What are the side effects of doxorubicin?

Answer 3

CHF

Question 4

What are the side effects of cyclophosphamide?

Answer 4

Hemorrhagic cystitis

Question 5

Mechanism of vincristine and vinblastine (vinca alkaloids)

Answer 5

Inhibit microtubule formation in M phase

Question 6

Classic adverse effect of vincristine

Answer 6

Neurotoxicity (peripheral neuropathy)

Question 7

Topoisomerase I and II inhibitors affect which phase of cell cycle

Answer 7

S (DNA replication phase)

Question 8

Antimetabolites (methotrexate, 5-fu) affect which phase of cell cycle

Answer 8

S (DNA replication)

Question 9

Intercalating agents (bleomycin and doxorubicin) affect which stage of cell cycle

Answer 9

G2 (DNA proofreading)

Question 10

Vinca alkaloids and taxans affect which stage of cell cycle

Answer 10

M (cell division)

Question 11

What is occurring in the G1 phase

Answer 11

Building blocks for DNA synthesis are being prepared