GI Physiology Flashcards
What are the VACTERL defects associated with omphalocele?
Vertebral defects, Anal atresia, Cardiac Defects, TEF, Renal defects, Limb defects
associated with aneuploidy
Omphalocele and Gastrochisis result from defect of which ventral wall closer?
Lateral wall
Rostral fold closure results in which ventral wall defect?
Sternal defect
Caudal fold closure defect results in which ventral wall defect
Bladder exstrosphy
Polyhdramnios, drool, choking, vomiting with first feeding and air in stomach suggest which anomaly?
Tracheoesophageal fistula (esophageal atresia)
Cause of duodenal atresia
Failure to recanalize
“double bubble” on X-ray with bilous vomiting and abdominal distension in first 1-2 days of life suggest
duodenal atresia
“triple bubble sign” with bilious vomiting and abdominal distension in first two days of life suggest
jejunal and ileal atresia
cause of jejunal and ileal atresia
disruption of superior mesenteric vessels–> ischemic necrosis–> segmental resorption
Common cause of jejunal and ileal atresia
Malrotation leading to occlusion of SMA and ischemic necrosis
A “palpable olive mass” in epigastric region and nonbilous projectile vomiting at 2-6 weeks old is suggestive of
Hypertrophic Pyloric stenosis
Maternal use of macrolides during pregnancy is associated with
Hypertrophic pyloric stenosis
Hypokalemic, hypochloremic metabolic alkalosis in a hungry, dehydrated baby suggest
Hypertrophic pyloric stenosis
The uncinate process and main pancreatic duct are derived from
Ventral pancreatic buds
The body, tail, isthmus and accessory pancreatic duct are derived from
Dorsal pancreatic bud
What is special about the spleen’s embryologic arrangement
Derived from mesentery of stomach (mesoderm) but has foregut supply (splenic artery)
Retroperitoneal structures (SADPUCKER)
Suprarenal (adrenal) glands Aorta and IVC Duodenum (2 and 4) Pancreas (except tail) Ureters Colon (ascending and descending) Kidneys Esophagus (thoracic) Rectum (partially)
Foregut structures supplied by celiac artery
lower esophagus to proximal duodenum, liver, gallbladder, pancreas, spleen
Midgut structures supplied by SMA
Distal duodenum to proximal 2/3 of transverse colon
Hindgut structures supplied by IMA
Distal 1/3 of transverse colon to upper portion of rectum
What is SMA syndrome (Wilkie’s syndrome)
Occasional post-prandial pain due to compression of third portion of duodenum between SMA and aorta; occurs in malnutrition/low body weight
Which arteries provide anastamoses between IMA and SMA?
Middle colic (SMA) and Left colic (IMA)
The right gastric artery branches off of which vessel?
Proper hepatic arterty
Three GI arteries that branch off of celiac
Common hepatic, L. gastric, Splenic
The short gastrics and L. gastroepiploic arteries branch off of
Splenic artery
Lower esophagus blood is provided by
Left gastric artery
Superior hemorrhoids occur in which vein
Superior rectal
Anorectal varices in cirrhosis occur due to anastomosies between
Superior rectal and middle and inferior rectal vein s
Caput medusae around umbilicus occurs due to anastamoses between which two veins?
Paraumbilical to small epigasteric veins of small anterior abdominal wall
Esophageal varices occur due to abnormal anastamoses between
Left gastric and azygos
What is TIPS
Transjugular intrahepatic portosystemic shunt to treat portal hypertension
How is TIPS performed
Shunt placed between portal vein and hepatic vein to bypass liver and shunt blood to systemic circulation
Which structure is formed where endoderm meets ectoderm
Pectinate (dentate) line
Why are internal hemorrhoids not painful
Receive visceral innervation
Lymph drainage of structures above pectinate line
Internal iliac lymph nodes
Arterial supply of structures above pectinate line
Superior rectal artery
Arterial supply of structures below pectinate line
Inferior rectal artery (branch of internal pudendal)
Venous drainage of structures below pectinate line
Inferior rectal vein–> internal pudendal vein–> internal iliac vein–> common iliac vein–> IVC
Venous drainage of structures above pectinate lin e
Superior rectal vein –> inferior mesenteric vein–> portal vein
Lymphatic drainage of structures below pectinate line
Superficial inguinal lymph nodes
Inferior rectal branch of pudendal nerve innervates which part of body
Structures below pectinate line (external hemorrhoids–painful)
Which hepatic zone contains P450, is most sensitive to metabolic toxins, is first affected by ischemia, and is the first site of alcoholic hepatitis?
Zone 3 (pericentral vein/centrilobular zone)
Which hepatic zone is affected by yellow fever?
Zone 2 (Intermediate zone)
Which hepatic zone is affected first by viral hepatitis and bacterial/infectious toxins?
Zone 1 (Periportal zone)
Which cells store Vitamin A when quiescent and produce ECM when active?
Hepatic stellate (Ito) cells in space of Disse
Which cells are the macrophages of the liver?
Kupffer cells lining sinusoids
What is the site of protrusion of indirect hernia
Deep (internal) inguinal ring
What is the site of protrusion of direct hernia?
Abdominal wall
The internal spermatic fascia forms from the
Transversalis fascia
The cremasteric muscle and fascia form from
Internal oblique
The external spermatic fascia form from
External oblique
ICE tie
Internal spermatic fascia - transversalis fascia
Cremasteric muscle and fascia- internal oblique
External spermatic fascia- external oblique
What is the site of femoral hernias
Femoral ring
What is the most common cause of indirect inguinal hernias in males
Patent processus vaginalus (risk of hydrocele)
Which anatomic structures help distinguish Indirect hernias from direct hernias?
Inferior Epigasteric vessels
Location of direct hernia relative to inferior epigastric vessel
Medial to inferior epigastric vessel
Location of indirect hernia relative inferior epigastric vessel
Lateral to inferior epigastric vessels
Internal ingunal ring, external inguinal ring, into scrotum (which hernia)
Indirect inguinal
Two complications of hernias
Incarceration (not reducible back into abdomen/pelvis) and strangulation (ischemia and necrosis)
Cutting which ligament provides access to pancreas in lesser sac during surgery?
Gastrocolic
Which structure does direct inguinal hernia go through
External inguinal ring
What is direct inguinal hernia covered with and who usually gets it
External spermatic fascia; older men
What are the borders of Hesselbach’s triangle
Superior: Inferior epigasteric vessels
Medial: Lateral border of rectus abdominus
Inferior: Inguinal ligament
Where does femoral hernia protrude through and who usually gets it
Below inguinal ligament through femoral canal; females
What is the risk assocaited with femoral hernias
Incarceration and strangulation
Cause of umbilical hernias
Weakened rectus abdominus muscle; protrusion of allantois remnant
Why do diaphragmatic hernias typically occur on left side?
The right hemidiaphgragm is protected by the liver
What is the most common diaphragmatic hernia?
Sliding hiatal hernia (gasteroesophageal junction displaced upward) “Hourglass stomach”
Sliding hiatal hernias are associated with which condition
GERD
Presentation of diaphragmatic hernia on newborn
Tachypnea, dyspnea, cyanosis, absent bowel sounds, scaphoid abdomen, hypoplastic left lung
dx with US
Risk of paraesophageal diaphragmatic hernia
gastric volvulus (stomach fundus flips onto itself, GE junction is usually normal)
Which three conditions increase gastrin production?
Chronic PPI use, Zollinger-Ellison syndrome (gastrinoma), H Pylori
Which medications increase motilin and thus migrating motor complexes
Erythromyciin
Clinical presentation of VIPoma
Watery diarrhea, Hypokalemia and Achlorydia (WDHA syndrome)
What causes increased lower esophageal sphincter tone in achalasia
Loss of NO
What converts trypsinogen to trypsin and where is it found
Enterokinase/enteropeptidase, brush border of duodenal and jejunal mucosa
Where is Iron (Fe+2) absorbed
Duodenum
Where is Folate absorbed
Jejunum
Where is B12 absorbed
Terminal ileum along with bile salts; requires intrinsic factor
Where do you find Peyer’s patches
Lamina propria and submucosa of ileum
Predominant antibody of Peyer’s patches
IgA
Which enzyme catalyzes rate-limiting step of bile acid synthesis
Cholesterol-7 alpha-hydroxylase
Three major functions of bile
- Digestion and absorption of lipids and fat-soluble vitamins
- Cholesterol excretion
- Antimicrobial activity
6 components of Bile
Bile salts (bile acids + Glycine/Taurine) Ions Water Cholesterole Biliirubin Phospholipids
What is bilirubin conjugated with
Glucuronate by UGT1
How is unconjugated bilirubin transported in blood
Attached to albumin
Failure of facial prominences to fuse causes
Cleft lip and palate
What is Behcet syndrome
Recurrent apthuous uclers, genital ulcers and uveitis due to immune complex vasculitis involving small vessels
What are the major risk factors for squamous cell carcinoma of oral cavity
Tobacco and alcohol
Leukoplakia and erythroplakia must be biopsied to rule out
Squamous cell carcinoma
What causes Hairy leukoplakia
EBV induced squamous cell hyperplasia in immunocompromised individuals; occurs on lateral tongue
Mobile, painless, circumscribed mass at angle of jaw is suggestive of which condition and containes which tissues
Pleomorphic adenoma; stromal and epithelial tissue
Most common salivary gland tumor
Pleomorphic adenoma
Common site of Warthin tumor
Parotid gland
Histology of Warthin tumor
Abundant lymphocytes and germinal centers (lymph-node like stroma); benign tumor
Most common cause of sialadenitis
S. aureus infection following obstructing stone
Most common malignant tumor of parotid gland
Mucoepidermoid carcinoma (mucinous and squamous cells)
Why does mucoepidermoid carcinoma cause pain
Involves facial nerve
Clinical presentation of Plummer-Vinson syndrome
1) Dysphagia
2) Esophageal web
3) Iron deficiency anemia
Increased risk of squamous cell carcinoma