Antibiotics

Question 1

Which antibiotics inhibit cell wall synthesis

Answer 1

Cephalosporins (cefuroximine) and Penicillins

Question 2

How does vancomycin function

Answer 2

inhibits cell wall synthesis

Question 3

Which antibiotic inhibits 50S bacterial ribosomal subunit?

Answer 3

Chloramphenicol

Question 4

Which antibiotic can cause aplastic anemia?

Answer 4

Chloramphenicol

Question 5

Macrolide antibiotics, chloramphenicol and linezolid mechanism

Answer 5

Inhibit bacterial 50S ribosomal subunit

Question 6

Fluoroquinolone (Ciprofloxacin) mechanism

Answer 6

Inhibit bacterial DNA gyrase leading to bacterial DNA damage and cell death

Question 7

Which antibiotics inhibit bacterial 30S ribosomal subunit

Answer 7

Doxycycline, tetracycline, minocycline and aminoglycosides

Question 8

What is the mechanism of Rifampin?

Answer 8

Inhibit bacterial DNA-dependent RNA polymerase

Question 9

GI side effects, rash, red-orange body fluids and cytopenias are side effects of which TB medication

Answer 9

Rifampin

Question 10

Mechanism of Isoniazid

Answer 10

Inhibit mycolic acid synthesis

Question 11

Side effects of Pyrazinamide

Answer 11

Hepatotoxicity, hyperuricemia

Question 12

Side effect of Ethambutol

Answer 12

Optic neuropathy

Question 13

Which TB medication supposedly inhibits arabinosyl transferase

Answer 13

Ethambutol

Question 14

How does penicillin affect gram negative bacteria

Answer 14

Covalently bond and inhibit transpeptidase to terminal D-ala-D-ala and inhibit cell wall synthesis

Question 15

Which bacteria is Daptomycin effective against

Answer 15

Gram +

Question 16

Daptomycin mechanism

Answer 16

Depolarizes cell membrane by creating transmembrane channels

Question 17

Side effects of daptomycin

Answer 17

Myopathy and CPK elevation; inactivated by pulm surfactant so can’t treat pneumonia

Question 18

Thrombocytopenia, optic neuritis and increased risk of serotonin syndrome are side effects of

Answer 18

Linezolid

Question 19

Techoic acid is a molecule part of which bacteria?

Answer 19

Gram positive

Question 20

Which component of gram positive bacteria is an antigenic target for human immune system

Answer 20

Techoic acid

Question 21

Which bacteria have LPS

Answer 21

Gram negative

Question 22

Which antibiotic is effective against aspiration pneumonia lung abscesses?

Answer 22

Clindamycin

Question 23

Which antibiotic has activity against aerobes and anaerobes by disrupting 50s protein synthesis ?

Answer 23

Clindamycin