Antibiotics Flashcards
Which antibiotics inhibit cell wall synthesis
Cephalosporins (cefuroximine) and Penicillins
How does vancomycin function
inhibits cell wall synthesis
Which antibiotic inhibits 50S bacterial ribosomal subunit?
Chloramphenicol
Which antibiotic can cause aplastic anemia?
Chloramphenicol
Macrolide antibiotics, chloramphenicol and linezolid mechanism
Inhibit bacterial 50S ribosomal subunit
Fluoroquinolone (Ciprofloxacin) mechanism
Inhibit bacterial DNA gyrase leading to bacterial DNA damage and cell death
Which antibiotics inhibit bacterial 30S ribosomal subunit
Doxycycline, tetracycline, minocycline and aminoglycosides
What is the mechanism of Rifampin?
Inhibit bacterial DNA-dependent RNA polymerase
GI side effects, rash, red-orange body fluids and cytopenias are side effects of which TB medication
Rifampin
Mechanism of Isoniazid
Inhibit mycolic acid synthesis
Side effects of Pyrazinamide
Hepatotoxicity, hyperuricemia
Side effect of Ethambutol
Optic neuropathy
Which TB medication supposedly inhibits arabinosyl transferase
Ethambutol
How does penicillin affect gram negative bacteria
Covalently bond and inhibit transpeptidase to terminal D-ala-D-ala and inhibit cell wall synthesis
Which bacteria is Daptomycin effective against
Gram +
Daptomycin mechanism
Depolarizes cell membrane by creating transmembrane channels
Side effects of daptomycin
Myopathy and CPK elevation; inactivated by pulm surfactant so can’t treat pneumonia
Thrombocytopenia, optic neuritis and increased risk of serotonin syndrome are side effects of
Linezolid
Techoic acid is a molecule part of which bacteria?
Gram positive
Which component of gram positive bacteria is an antigenic target for human immune system
Techoic acid
Which bacteria have LPS
Gram negative
Which antibiotic is effective against aspiration pneumonia lung abscesses?
Clindamycin
Which antibiotic has activity against aerobes and anaerobes by disrupting 50s protein synthesis ?
Clindamycin
