Pharmacology primer Flashcards
Suffix for ACE inhibitors? MOA?
-pril; Inhibits conversion of Angiotensin 1 to Angiotensin 2.
Also prevents Angiotensin 2 induced release of aldosterone.
Suffix for DHP calcium channel blocker? MOA?
-dipine; Causes peripheral vasodilation.
Suffix for thiazide diuretics? MOA?
-thiazide; Increases excretion of sodium and water to decrease edema.
Suffix for Angiotensin Receptor Blocker? MOA?
-sartan; Blocks Angiotensin 2 from binding to receptor
Prevents Angiotensin 2 induced release of aldosterone
Suffix for Alpha 1 Antagonists? MOA?
- zosin; Blocks NE effect on alpha receptors, preventing vasoconstriction
MOA of nitrates?
Directly relaxes vascular smooth muscle
Suffix for Class 3 Antiarrhythmic? MOA?
-darone or -tilide;
K channel blocker that prolong action potentials
Suffix for Statins? MOA?
-statin; Interferes with hepatic biosynthesis of mevalonate, decreasing cholesterol synthesis and upregulates LDL receptors.
MOA of Beta blockers?
Block sympathetic activation of beta receptors; Slow HR and decrease contractility
MOA of NDHP Calcium channel blockers?
Blocks Calcium channels on myocardial tissue; Decreases HR and CO
MOA of Alpha 2 Agonist?
“Shut off valve” to SNS; tells body to stop secreting NE
MOA of Renin inhibitor?
Blocks RAAS at point of activation by inhibiting renin release
MOA of Loop Diuretics?
Decreases Na and Cl reabsorption in the loop of henle and distal convoluted tubule
MOA of Potassium Sparing Diuretics
Blocks aldosterone from causing water retention;
Inhibits Na reabsorption at the distal convoluted tubule, decreasing water reabsorption and increasing K retention
Discuss Ramolazine
Inhibits late phase APs; No effect on BP or HR
Increases exercise tolerance and decreases frequency of angina
Uses of Ramolazine
CAD pts with comorbid conditions.
Pts who have failed other therapies
Dont use for Acute angina
Adverse effects of Ramolazine?
Constipation/Nausea
MOA of Digoxin?
Enhance contractility by inhibiting Na/K ATPase pump
Differentiate the classes of Antiarrhythmic drugs.
Class 1: Na channel blockers, slows conduction
Class 2: Beta blockers
Class 3: K channel blocker, prolong APs
Class 4: NDHP Ca channel blockers
MOA of Fibric Acids?
Increase lipoprotein lipase, decreases apoC3, decreases TGs
MOA of Bile Acid Resins?
Binds bile acid in GI tract
MOA of Niacin?
Inhibits lipolysis and synthesis of TG
Discuss Nitrates
Directly relax smooth muscle by releasing NO; Reduces myocardial oxygen demand
Adverse effects of Nitrates?
Tolerance; Contraindicated with PDE-5 inhibitors (Erectile dysfunction meds), may cause severe hypotension and death
Therapuetic effects of nitrates?
1. Inhibits coronary vasoconstriction. 2 Increases perfusion of myocardium 3. Diminished venous return 4. Decreased arterial pressure at higher doses. Use for Acute situations.
