Anti-platelet pharmacology

Question 1

MOA of aspirin

Answer 1

Prevents formation of thromboxane A2 by inhibition

Question 2

MOA of clopidogrel

Answer 2

Thienopyridine prodrug that irreversibly blocks the G coupled platelet ADP receptor (P2Y12) and inhibits platelet aggregation
Requires CYP2C19 for activation

Question 3

MOA of Prasugrel

Answer 3

Thienopyridine prodrug but does not require CYP2C19 for activation
-Binds irreversibly to P2Y12 ADP receptors

Question 4

MOA of Ticagrelor

Answer 4

Cyclopentyltriazolopyrimidine which binds reversibly to P2Y12 ADP receptors

Question 5

MOA of Cangrelor

Answer 5

Nonthienopyridine ATP analog which binds reversibly to P2Y12 ADP receptors to prevent platelet activation

Question 6

MOA of Vorapaxar

Answer 6

• Oral protease activated receptor 1 (PAR-1) antagonist

- PAR-1 is important receptor on platelets

Question 7

MOA of Streptokinase, Alteplase, Reteplase, and Tenecteplase

Answer 7

Act rapidly to lyse thrombi by catalyzing the formation of plasmin (a serine protease) from plasminogen