Lipid Pharmacology Flashcards
1
Q
MOA of statins
A
- Inhibit HMG CoA reductase
2. Decrease cholesterol synthesis
2
Q
Adverse effect of statins
A
myopathy
3
Q
Name the Fibric Acids
A
Gemfibrozil
Fenofibrate
Fenofibric Acid
4
Q
MOA of Fibric Acids
A
Degrades lipoproteins, Decreases TG, increases FA oxidation
5
Q
Adverse effects of Fibric Acids
A
Dyspepsia, gallstones, urticaria, hair loss, myopathy
6
Q
Name Bile Acid Resins
A
Cholestyramine
Colestipol
Colesevelam
7
Q
Name cholesterol Absorption blockers
A
Ezetimibe
8
Q
MOA of cholesterol absorption blockers
A
inhibits cholesterol transport in intestines via NPC1L1
9
Q
Name the PCSK inhibitors
A
Evolocumab, Alvorucumab
10
Q
MOA of PCSK inhibitors
A
PCSK9 promotes intracellular degradation of LDL receptors so that the receptors are not recycled to continue uptake of LDL
-These drugs wall off PCSK9 to allow receptor recycling
