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Neuroscience (1206) > Pharmacology of Neuromuscular Transmission > Flashcards

Pharmacology of Neuromuscular Transmission Flashcards

1
Q

The Action potential generated is propagated along the ______ and down the ______ tubules.

A

Sarcolemma, T

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2
Q

In AP Propagation, Ca 2+ ions bind to _____, which changes the shape and removes the blocking action of ______, leaving the actin active sites exposed.

A

Troponin, Tropomyosin

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3
Q

In contraction, ____ cross bridges alternately attach to actin and detach, pulling the actin filaments towards the centre of the _____.

A

Myosin, Sarcomere

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4
Q

How many subunits make up the Nicotinic receptors

A

5

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5
Q

List the 5 subunits of the nicotinic receptors

A

2 alpha, 3 non alpha subunits,

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6
Q

List the subunits that make up the ganglionic nicotinic receptor

A

2 alpha, 3 beta

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7
Q

True or false, prolonged opening of nicotinic Na+ channels, prolongs inactivation of the immediate surrounding Na+ ion channels.

A

True

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8
Q

What two drugs interfere with the non-depolarising postsynaptic action of ACh

A

Pancuronium, Mivacurium

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9
Q

True or false, Pancuronium is a competitive agonist of nicotinic receptors

A

False, Antagonist

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10
Q

True or False, Mivacurium binds to and prevents the action of ACh, this decreasing AP development

A

True

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11
Q

What drug interferes with the Depolarizing postsynaptic action of ACh

A

Succinylcholine (suxamethonium)

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12
Q

True or false succinylcholine is an antagonist of nicotinic receptors

A

False, it is an agonist

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13
Q

True or false, Acetylcholinesterase can metabolise succinylcholine

A

False, it can’t

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14
Q

True or False, Succinylcholine causes persistent depolarisation of the nicotinic sodium channels

A

True

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15
Q

True or False, Succinylcholine causes a blockade of voltage-gated sodium channel

A

True

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16
Q

What are some clinical applications of Drugs that induces skeletal muscle paralysis

A

DURING ENDOTRACHEAL INTUBATION
DURING ORTHOPEDIC MANIPULATION
TO ALLEVIATE THE PERIPHERAL SYMPTOMS OF CONVULSION
TO PROVIDE CONTROLLED VENTILATION (OBSTRUCTIVE
AIRWAY DISEASE)

17
Q

List the drugs that are short acting in inducing paralysis (5-15mins)

A

SUCCINYLCHOLINE, MIVACURIUM

18
Q

List the drug that is long lasting in inducing paralysis (30-120 mins)

A

Pancuronium

19
Q

What is the time taken for the onset of paralysis inducing drugs

A

<5 mins

20
Q

True or false Succinylcholine is a very polar agent

A

True

21
Q

True or false, Mivacurim has charged N groups and is similar to Each

A

True

22
Q

What is the normal route of administration for Paralysis inducing drugs

A

IV or IM

23
Q

What is the removal site for Succinylcholine and Mivacurium

A

Psuedocholinesterase

24
Q

What is the removal site for Pancuronium

A

Renal

25
Q

What drug produces the adverse drug reaction: M2 MUSCARINIC RECEPTOR BLOCKADE

A

Pancuronium

26
Q

What drug produces the adverse drug reaction: HISTAMINE RELEASE

A

Mivacurium, Succinylcholine

27
Q

What drug produces the adverse drug reaction: MALIGNANT HYPERTHERMIA

A

Succinylcholine

28
Q

What drug produces the adverse drug reaction: INCREASE IOP

A

Succinylcholine

29
Q

What drug produces the adverse drug reaction: POST-OPERATIVE PAIN

A

Succinylcholine

30
Q

What drug produces the adverse drug reaction: Increase K+ release-HYPERKALEMIA

A

Succinylcholine

31
Q

True or false, succinylcholine is well absorbed orally

A

False

32
Q

What is the effect of administering anticholinesterase during succinylcholine paralysis

A

Deepened Paralysis

33
Q

In a patient given mivacurium, what is the likely effect of administering anticholinesterase

A

Reversal of paralysis

34
Q

True or false, relevant effects of mivacuriumcan be reversed by anticholinesterase

A

True

35
Q

True or False, the muscle recant succinylcholine blocks the action of acetylcholine on muscarinic receptors

A

False

36
Q

True or False, Muscarinic receptors are so named because they are more sensitive to muscarine than to nicotine.

A

True

37
Q

Where are muscarinic receptors found

A

brain, heart and smooth muscle

38
Q

What are the three neurotoxins that prevent neuronal Na+ action

A

Saxitoxin, Tetrodotoxin (puffer fish) , Ciguatoxin

Neuroscience (1206) (17 decks)

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