Genesis of Nerve Membrane Potential Flashcards
What is the resting membrane potential in nerve cells
-70mV
what is the resting membrane potential in cardiac and skeletal cells
-85mV to -90mV
What do all excitable tissues have
RMP
What is the average extracellular Na+ ion concentration
140mEq/L
What is the average extracellular K+ ion concentration
4mEq/L
What is the average extracellular Cl- ion concentration
125mEq/L
What is the average intracellular Na+ ion concentration
14mEq/L
What is the average intracellular K+ ion concentration
140mEq/L
What is the average intracellular Cl- ion concentration
9mEq/L
What causes the genesis of RMP in nerve cells
Non- diffusable proteins, uneven distribution of K+, Na+, Cl- and transport Proteins (Na/K pump, K+ leaky channel)
When 3___ flows out of the electrogenic pump, 2___ flows through the electrogenic pump
Na+, K+
What two forces help to regulate the movement of ions in and out of the cell
Diffusion forces, Electrostatic Forces
True or false, K+ ions are permeable to the cell membrane
True
True or False, Na+ ions are permeable to the cell membrane
False
True or False, Cl- ions are semi permeable to the cell membrane
True
Term given when the membrane potential at which the tendency to move against the electrical or concentration gradient is exactly balanced
Equilibrium Potential
What are the 3 assumptions of Nernst Equation
Membrane is selectively and totally permeable to each ion
Each ion is in electrochemical equilibrium across the membrane
Diffusing ion is isolated from all other ions
Term given to a decrease in Vm which results in nerve excitability
Hyperkelemia
