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BPT Flashcards > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

Pharmacokinetic parameter - Cmax/MIC

A

Aminoglycosides
Fluoroquinolones

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2
Q

Pharmacokinetic parameter - AUC/MIC

A

Vancomycin
Azithromycin
Fluoroquinolones
Aminoglycosides
Tigecycline
Linezolid

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3
Q

Pharmacokinetic parameter - T > MIC

A

Beta lactams
Vancomycin
Macrolides
Clindamycin

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4
Q

Site of action for acetazolamide

A

PCT

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5
Q

Site of action for furosemide

A

thick ascending loop of Henle
Inhibits sodium-potassium-chloride co-transporter (NKCC2)

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6
Q

Site of action for thiazide, metolazone, indapamide

A

DCT

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7
Q

Site of action for spironolactone

A

CD

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8
Q

Site of action for amiloride

A

DCT, connecting tubules, collecting ducts

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9
Q

Site of action for triamterene

A

Collecting tubule

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10
Q

Interactions that increase lithium concentrations

A

SSRIs
Metronidazole
Tetracyclines
Topiramate
NSAIDs
ACE inhibitors
Thiazide diuretics
Spironolactone
Furosemide
ARBs

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11
Q

Interactions that decrease lithium concentrations

A

Xanthines (theophylline, caffeine)
Sodium bicarbonate and sodium chloride containing products
Psyllium
Urea
Mannitol
Acetazolamide

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12
Q

Medications associated with photosensitivity

A

Doxycycline
Hydrochlorothiazide
Amiodarone
Chlorpromazine
Co-trimaxazole
Captopril
Enalapril
Carbamazepine
Bendroflumethiazide

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13
Q

Which medication has been associated with male breast cancer?

A

Finasteride
Type II 5-alpha-reductase inhibitor –> enzyme that metabolises testosterone into more potent androgen dihydrotestosterone

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14
Q

Most common side effect of quinine

A

Thrombocytopenia

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15
Q

Common adverse effects of lithium

A

Metallic taste
Diarrhoea
Muscle weakness
Epigastric discomfort
Weight gain
Vertigo
Leukocytosis
Hypothyroidism
Hypercalcaemia
Hyperparathyroidism
Benign T wave changes on ECG

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16
Q

Signs of severe lithium toxicity

A

Increased muscle tone
Hyperreflexia
Myoclonic jerks
Coarse tremor
Dysarthria
Disorientation
Psychosis
Seizures
Coma

17
Q

Important monitoring for patients on lithium

A

Baseline ECG
Weight
Renal function
SErum calcium
PTH
TFTs

Repeat every 3-6 months

18
Q

AEDs - sodium blockade

A

Carbamazepine
Lacosamide
Lamotrigine
Phenytoin
Zonisamide

19
Q

AEDs- a2-gamma modulation

A

Gabapentin
Pregabalin

20
Q

AEDs - Ca channel blockade

A

Ethosuximide
Lamotrigine
Zonisamide

21
Q

AEDs- modulation of SV2A mediated neurotransmitter release

A

Levetiracetam
Brivaracetam

22
Q

MOA of perampanel

A

AMPA antagonism

23
Q

AEDs - potentiates GABA activity

A

Barbiturates
Benzodiazepines
Valproate
Vigabatran

24
Q

Drug interaction between sodium valproate and lamotrigine

A

Lamotrigine metabolised by N-glucoronidation
Valproate causes rise in plasma concentration of Lamotrigine by competitively inhibiting glucoronidation

25
Q

Drug interaction between sodium valproate and carbapenems

A

Decreased efficacy of sodium valproate

26
Q

Carba/pheny/pheno/ox + lamotrigine drug interactions

A

CYP3A4 inducers –> decreases lamotrigine levels

27
Q

Carba/pheny/pheno/ox + OCP

A

Decreases efficacy of OCP

BPT Flashcards (32 decks)

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