Oncology Flashcards
PSA screening recommendations
Age - offer PSA testing every 2 yrs from 50-69
FHx
- one first degree relative 2.5-3x risk - from >45yrs
- 3x first degree relatives - from > 40 yrs
Prostate cancer investigations
Indicated if elevated PSA +/- abnormal DRE
MRI prostate
Multifocal core biopsy
Features suspicious of metastatic prostate cancer
PSA > 100ng/dl
Distribution of metastatic disease - sclerotic bone metastases
Prostate management options
Localised
- prostatectomy
- radiotherapy
Advanced disease
- hormonal therapy/bilateral orchiectomy
- chemotherapy
- supportive therapy –> RTx, bisphosphonates, palliative care
MOA of androgen deprivation therapy
ADT –> reduce GnRH –> reduce LH –> reduce testicular testosterone production
Side effects of ADT
Vasomotor symptoms
Reduced libido
Bone density loss
Muscle mass loss
Cardiovascular risk factors
Estrogen deficiency - gynaeocomastia, hot flushes
Testosterone deficiency - erectile dysfunction, diabetes, muscle weakness
Relationship between testosterone and estradiol
Testosterone converts to estrogen via CYP19/aromatase
Chemotherapy for prostate cancer
Taxanes - docetaxel, cabazitaxel
Used in combination with ADT for “high volume” disease, visceral metastases, multiple bone metastases
MOA of taxane chemotherapy
Interferes with microtubule growth, causing cell arrest in G2/M phase
Inactivates bcl-2 –> apoptosis
Side effects of taxane chemotherapy
Hair loss
N+V
Pancytopenia
Mucositis/diarrhoea
Lethargy
Fluid retention
Hypersensitivity reactions
Myalgias and arthralgias
Peripheral neuropathy
Nail changes
Examples of direct androgen receptor antagonist
Enzalutamide
Apalutamide
Darolutamide
Examples of androgen biosynthesis inhibitor (17a-hydroxylase)
Abiraterone
Blocks synthesis of testosterone in adrenal gland via inhibition of 17a-hydroxylase and C17,20-lyase activity
Mechanism of cortisol inhibition of abiraterone
Abiraterone (androgen biosynthesis inhibitor via 17a hydroxylase)
ACTH rises in response to increase in deoxycortisterone (due to decrease in 17OH-progesterone) –> leads to decrease in cortisol (thus should have mandatory concurrent steroids)
Also results in increased shunting, causing excess mineralocorticoid (hyperaldosteronism)
Side effects of direct androgen receptor antagonists
Fatigue
Cognitive impairment
Falls
Seizures
Rash
Side effects of androgen biosynthesis inhibitor
Cardiac toxicity
Hypertension
Concurrent steroids
Bone protection methods for prostate cancer
Calcium and vitamin D supplementation
Weight bearing exercise
DEXA scan monitoring
High risk - denosumab, ZA
Common complications of prostate cancer
Acute urinary retention
Bilateral ureteric obstruction
Spinal cord compression
Pancytopenia from BM infiltration
Bilateral lower limb lymphoedema secondary to pelvic obstruction
Genetic defects in prostate cancer
Aberrations in ~1/3rd of pts
BRCA2 most common alteration seen
Testicular cancer classification
Pure seminoma - AFP not elevated
Non seminoma/mixed germ cell tumour - often elevated
Testicular cancer epidemiology
Most commonly seen in 25-40 yrs
Median age at diagnosis is 33 yrs
Increased risk with cryptorchidism
5 yr relative survival ~98%
Tumour markers for prostate cancer
AFP, beta HCG, LDH
Role of AFP and beta HCG
Useful for surveillance/follow up
Associated with prognosis and used to guide treatment in advanced disease
Treatment of testicular cancer
Localised disease
- Orchiectomy
- Surveillance
Metastatic/advanced disease
- Chemotherapy (Bleomycin, etoposide, platinum)
- Resection of residual masses
Relapsed/refractory disease
- Second line chemotherapy
- High dose chemo and mini-autografts
Toxicities associated with chemotherapy for testicular cancer
Pancytopenia, alopecia, lethargy
Cisplatin
- Hearing impairment
- Tinnitus
- Peripheral neuropathy
- Renal impairment
Bleomycin
- Hypersensitivity
- Pneumonitis/lung toxicity
Risk factors for CRC
Excess body weight
Low levels of physical activity
High consumption of processed meat and EtOH
Low fibre consumption
Cigarette smoking
IBD
- Pancolitis > left sided colitis
- CD
FHx
Familial cancer syndromes
Common heritable syndromes for CRC
HNPCC/Lynch syndrome
FAP
Genetic factors for CRC
High penetrance genes - APC, biallelic MUTYH, BRCA1/2, PALB2, CDKN2A, TP53
Moderate penetrance genes - monoallelic MUTYH, APC allele, p.I1307K, CHEK 2
Characteristics of HNPCC/Lynch syndrome
Autosomal dominant, high penetrance
Mean age - 48 yrs
Defect in DNA mismatch repair (MMR) genes
Phenotype
- 60-70%: R sided/proximal colonic tumours
- 10% synchronous or metachronous tumours
- Polyps may be present, can overlap with AFAP
- Extracolonic tumours - endometrial, ovarian, stomach, SB, hepatobiliary, brain, renal, pelvis/ureter
Pts at risk of HNPCC
Amsterdam criteria
- >/ 3 relatives with Lunch associated Ca (of which one is a 1st degree relative)
- Lynch associated Ca involving at least 2 generations
- >/ 1 diagnosed before 50 yrs
Bethesda criteria
- CRC Dx < 50 yrs
- Synchronous, metachronous or other Lynch associated Ca, regardless of age
- CRC with MSI-like histology (TILs, mucinous/signet ring, poorly differentiated)
- >/ 1st degree relatives with Lynch associated Ca with 1 diagnosed < 50y/o
- CRC diagnosed in >/ 2 1st degree relatives with Lynch associated Ca
BRAFV600E mutation and Lynch syndrome
If BRAFV600E ABSENT - would rule out Lynch syndrome
MMR genes
MLH1, MSH2, MSH6, PMS2
MAPK pathway
EGFR > RAS > BRAF > MEK > ERK > cell growth and differentiation
BRAF mutation positive CRC
Poor prognosis
Poor response to standard chemo
Requires BRAF inhibitor with EGFR inhibitor (due to upregulation of EGFR in pathway)
FAP features
Germline mutation of APC gene on chromosome 5
FAP - Average age of polyposis 16 yrs (100-1000s), CRC by 45 yrs if untreated
–> screening from 10-15 yrs
AFAP - < 100 polyps, CRC 54 yrs
–> screening at 25 yrs
Colonoscopy timing for Lynch syndrome
1-2 yrly colonoscopies from age 25 yrs or 5 years younger than youngest affected case
Colonoscopy timing for APC mutation
Classic FAP
Surveillance from 10-15 yrs
Once adenoma detected, annual colonoscopy until total colectomy and ileorectal anastomosis
Examples and side effects of fluoropyrimidines
5-FU
Capecitabine
S/E:
Hand foot syndrome
Diarrhoea/mucositis
Haematological/myelosuppression
Coronary artery spasm
Acute coronary events
SEs of oxaliplatin
N+V, diarrhoea
Lethargy
Haematological/myelosuppression
Peripheral neuropathy - cumulative
Cold sensitivity/dysaesthesias
Laryngopharyngeal dysaesthesia
Hypersensitivity reaction
Factors to consider for treatment of CRC
L vs R sided primary
RAS/RAF status
MMR status
If metachronous/relapsed
Chemotherapy for metastatic CRC
Single agent:
- Fluoropyrimidines (5FU or capecitabine)
- Irinotecan
- TAS102
Doublet:
- Fluoropyrimidines with addition of oxaliplatin (FOLFOX/CAPOX) or irinotecan (FOLFIRI/CAPIRI)
Triplet: 5FU, oxiliplatin and irinotecan (FOLFOXIRI)
MOA and SE of irinotecan
Topoisomerase inhibitor
Metabolised by UGT1A1*28 genetic polymorphisms
S/E: Diarrhoea, anticholinergic effects, myelosuppression, alopecia
Targeted therapies for mCRC
VEGF inhibitors - bevacizumab (used regardless of RAS/RAF status, location)
EGFR inhibitor - cetuximab/panitumumab (only in RAS WT tumours, left sided primary)
Side effects of VEGF inhibitors
HTN
Delayed wound healing
Intestinal perforation/fistula formation
Proteinuria/nephrotic syndrome
Increased risk of bleeding/haemorrhage
Increased risk of arterial thrombotic events
Mechanisms of resistance for EGFR inhibitors
Downstream mutations of MAPK pathway
- KRAS/NRAS mutations
- BRAF mutations
S/E of EGFR inhibitors
- Cutaneous
- Skin - xerosis (dry skin), paronychia/fissures
- Diarrhoea
- Hypomagnesaemia
- Infusion reactions