Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BPT Flashcards > CYP > Flashcards

CYP Flashcards

1
Q

CYP1A2 substrates

A

Theophylline
Paracetamol
Haloperidol
Caffeeine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

CYP1A2 inhibitors

A

Ciprofloxacin
Fluvoxamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

CYP1A2 inducers

A

Smoking

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

CYP2C19 substrates

A

PPI
Clopidogrel
AEDs
Indomethacin
Escitaloprim

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

CYP2C19 inducers

A

Antifungals e.g. itraconazole, ketoconazole, fluconazole
Cimetidine
Isoniazid
PPIs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

CYP2C19 inducers

A

Carbamazepine
Rifampicin
St John’s Wort
Prednisone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

CYP2C9 substrates

A

NSAIDs
Warfarin
AEDs
Angiotensin II antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

CYP2C9 inhibitors

A

Sulfonamides
Sodium valproate
Metronidazole
Amiodarone
Antifungal e.g. itraconazole, ketoconazole, fluconazole
Chloramphenicol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

CYP2C9 inducers

A

Griseofulvin
St John’s wort
Rifampicin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

CYP2D6 substrate

A

Tamoxifen
Beta blockers
Antipsychotics e.g. haloperidol
Antidepressants
Antiarrhythmics e.g. flecainide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

CYP2D6 inhibitors

A

Amiodarone
Antipsychotics and antidepressants e.g. fluoxetine, duloxetine, paroxetine
Metoclopramide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

CYP2D6 inducers

A

Rifampicin
Dexamethasone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

CYP2E1 substrates

A

Ethanol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

CYP2E1 inhibitors

A

Disulfarim
Acute consumption of ethanol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

CYP2E1 inducers

A

Isoniazid
Chronic consumption of ethanol
Nicotine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

CYP3A4 substrates

A

Statins (except pravastatin)
Steroid hormones
Oral contraceptives
Carbamazepine and other anti-epileptic drugs
Haloperidol
Immunosuppressives - cyclosporin, tacrolimus
Macrolides
Benzodiazepine
Warfarin
Anti HIV medication
Calcium channel blockers
Itraconazole

17
Q

Carbamazepine autoinduction mechanism

A

Carbamazepine is inducer AND substrate of CYP3A4
Results in drug tolerance

18
Q

CYP3A4 inhibitors

A

Amiodarone
Macrolides - erythromycin, clarithmycin
Anti-HIV medications e.g. ritonavir
Grapefruit juice
Cimetidine
Chloramphenicol
Antifungals - itraconazole, ketoconazole, fluconazole

19
Q

CYP3A4 inducers

A

Chronic alcohol use
Carbamazepine
Rifampicin
St John’s wort
Anti-HIV medications
Griseofulvin
Nevirapine
Barbiturates e.g. phenobarbital
Phenytoin
Glucocorticoids

20
Q

QT prolonging drugs

A

Antipsychotics - haloperidol, ziprasidone, quetiapine, thioridazine, olanzapine, risperidone, droperidol
Antiarrhythmics - amiodarone, sotalol, procainamide, quinidine, flecainide
Antibiotics - macrolides, fluoroquinolones
Antidepressants - amitriptyline, imipramine, citalopram
Other - methadone, sumatriptan, ondansetron, cisapride

BPT Flashcards (32 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions