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CYP Flashcards

1
Q

CYP1A2 substrates

A

Theophylline
Paracetamol
Haloperidol
Caffeeine

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2
Q

CYP1A2 inhibitors

A

Ciprofloxacin
Fluvoxamine

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3
Q

CYP1A2 inducers

A

Smoking

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4
Q

CYP2C19 substrates

A

PPI
Clopidogrel
AEDs
Indomethacin
Escitaloprim

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5
Q

CYP2C19 inducers

A

Antifungals e.g. itraconazole, ketoconazole, fluconazole
Cimetidine
Isoniazid
PPIs

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6
Q

CYP2C19 inducers

A

Carbamazepine
Rifampicin
St John’s Wort
Prednisone

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7
Q

CYP2C9 substrates

A

NSAIDs
Warfarin
AEDs
Angiotensin II antagonist

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8
Q

CYP2C9 inhibitors

A

Sulfonamides
Sodium valproate
Metronidazole
Amiodarone
Antifungal e.g. itraconazole, ketoconazole, fluconazole
Chloramphenicol

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9
Q

CYP2C9 inducers

A

Griseofulvin
St John’s wort
Rifampicin

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10
Q

CYP2D6 substrate

A

Tamoxifen
Beta blockers
Antipsychotics e.g. haloperidol
Antidepressants
Antiarrhythmics e.g. flecainide

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11
Q

CYP2D6 inhibitors

A

Amiodarone
Antipsychotics and antidepressants e.g. fluoxetine, duloxetine, paroxetine
Metoclopramide

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12
Q

CYP2D6 inducers

A

Rifampicin
Dexamethasone

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13
Q

CYP2E1 substrates

A

Ethanol

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14
Q

CYP2E1 inhibitors

A

Disulfarim
Acute consumption of ethanol

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15
Q

CYP2E1 inducers

A

Isoniazid
Chronic consumption of ethanol
Nicotine

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16
Q

CYP3A4 substrates

A

Statins (except pravastatin)
Steroid hormones
Oral contraceptives
Carbamazepine and other anti-epileptic drugs
Haloperidol
Immunosuppressives - cyclosporin, tacrolimus
Macrolides
Benzodiazepine
Warfarin
Anti HIV medication
Calcium channel blockers
Itraconazole

17
Q

Carbamazepine autoinduction mechanism

A

Carbamazepine is inducer AND substrate of CYP3A4
Results in drug tolerance

18
Q

CYP3A4 inhibitors

A

Amiodarone
Macrolides - erythromycin, clarithmycin
Anti-HIV medications e.g. ritonavir
Grapefruit juice
Cimetidine
Chloramphenicol
Antifungals - itraconazole, ketoconazole, fluconazole

19
Q

CYP3A4 inducers

A

Chronic alcohol use
Carbamazepine
Rifampicin
St John’s wort
Anti-HIV medications
Griseofulvin
Nevirapine
Barbiturates e.g. phenobarbital
Phenytoin
Glucocorticoids

20
Q

QT prolonging drugs

A

Antipsychotics - haloperidol, ziprasidone, quetiapine, thioridazine, olanzapine, risperidone, droperidol
Antiarrhythmics - amiodarone, sotalol, procainamide, quinidine, flecainide
Antibiotics - macrolides, fluoroquinolones
Antidepressants - amitriptyline, imipramine, citalopram
Other - methadone, sumatriptan, ondansetron, cisapride

BPT Flashcards (32 decks)

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