CYP Flashcards
CYP1A2 substrates
Theophylline
Paracetamol
Haloperidol
Caffeeine
CYP1A2 inhibitors
Ciprofloxacin
Fluvoxamine
CYP1A2 inducers
Smoking
CYP2C19 substrates
PPI
Clopidogrel
AEDs
Indomethacin
Escitaloprim
CYP2C19 inducers
Antifungals e.g. itraconazole, ketoconazole, fluconazole
Cimetidine
Isoniazid
PPIs
CYP2C19 inducers
Carbamazepine
Rifampicin
St John’s Wort
Prednisone
CYP2C9 substrates
NSAIDs
Warfarin
AEDs
Angiotensin II antagonist
CYP2C9 inhibitors
Sulfonamides
Sodium valproate
Metronidazole
Amiodarone
Antifungal e.g. itraconazole, ketoconazole, fluconazole
Chloramphenicol
CYP2C9 inducers
Griseofulvin
St John’s wort
Rifampicin
CYP2D6 substrate
Tamoxifen
Beta blockers
Antipsychotics e.g. haloperidol
Antidepressants
Antiarrhythmics e.g. flecainide
CYP2D6 inhibitors
Amiodarone
Antipsychotics and antidepressants e.g. fluoxetine, duloxetine, paroxetine
Metoclopramide
CYP2D6 inducers
Rifampicin
Dexamethasone
CYP2E1 substrates
Ethanol
CYP2E1 inhibitors
Disulfarim
Acute consumption of ethanol
CYP2E1 inducers
Isoniazid
Chronic consumption of ethanol
Nicotine
CYP3A4 substrates
Statins (except pravastatin)
Steroid hormones
Oral contraceptives
Carbamazepine and other anti-epileptic drugs
Haloperidol
Immunosuppressives - cyclosporin, tacrolimus
Macrolides
Benzodiazepine
Warfarin
Anti HIV medication
Calcium channel blockers
Itraconazole
Carbamazepine autoinduction mechanism
Carbamazepine is inducer AND substrate of CYP3A4
Results in drug tolerance
CYP3A4 inhibitors
Amiodarone
Macrolides - erythromycin, clarithmycin
Anti-HIV medications e.g. ritonavir
Grapefruit juice
Cimetidine
Chloramphenicol
Antifungals - itraconazole, ketoconazole, fluconazole
CYP3A4 inducers
Chronic alcohol use
Carbamazepine
Rifampicin
St John’s wort
Anti-HIV medications
Griseofulvin
Nevirapine
Barbiturates e.g. phenobarbital
Phenytoin
Glucocorticoids
QT prolonging drugs
Antipsychotics - haloperidol, ziprasidone, quetiapine, thioridazine, olanzapine, risperidone, droperidol
Antiarrhythmics - amiodarone, sotalol, procainamide, quinidine, flecainide
Antibiotics - macrolides, fluoroquinolones
Antidepressants - amitriptyline, imipramine, citalopram
Other - methadone, sumatriptan, ondansetron, cisapride