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Antibodies/Biopsy findings Flashcards

1
Q

Anti-Ro

A

SLE
Neonatal heart block
Primary Sjogren’s

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2
Q

Anti-La

A

Primary Sjogrens

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3
Q

Anti-centromere

A

CREST syndrome
Limited sclerosis

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4
Q

Anti-dsDNA

A

SLE

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5
Q

Anti-Jo1

A

Inflammatory myopathy

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6
Q

Anti-U1-RNP

A

MCTD

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7
Q

Anti-Sm

A

Specific for SLE
Associated with CNS lupus, GN, African American, Poor prognosis

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8
Q

Anti-topoisomerase (Anti-Scl70)

A

Diffuse sclerosis
Higher risk of IPF

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9
Q

Anti-histone

A

SLE
Drug induced lupus

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10
Q

Anti-CCP

A

RA

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11
Q

Rheumatoid factor

A

RA
SLE

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12
Q

Anti-thrombin

A

SLE

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13
Q

c-ANCA (PR3)

A

GPA

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14
Q

p-ANCA (MPO)

A

MPA
EGPA
Systemic vasculitides
Primary sclerosing cholangitis
Ulcerative colitis

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15
Q

Anti-SRP

A

Polymyositis
IMNM

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16
Q

Anti-RNA polymerase III

A

Renal crisis in systemic sclerosis

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17
Q

Anti-Ro52

A

Systemic sclerosis (2nd most common antibody after anti-SCL70)
ILD
Dermatomyositis

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18
Q

Anti-p155

A

Dermatomyositis
Associated with malignancy and more severe cutaneous involvement

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19
Q

Anti-HMGCR

A

Statin induced necrotising mysotisi

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20
Q

BAFF + IL-6

A

GCA
PMR

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21
Q

Anti-tTG

A

Coeliac diseaseA

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22
Q

Anti-eTG

A

Dermatitis herpetiformis

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23
Q

Anti-actin

A

Coeliac

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24
Q

Anti-LKM1

A

type 2 autoimmune hepatitis

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25
Q

Anti-SMA

A

Chronic autoimmune hepatitis

26
Q

AMA

A

Primary biliary cirrhosis
AIH type 1

27
Q

Anti Saccharomyces cerevisiae antibody

A

Crohn’s disease

28
Q

Anti GQ1B

29
Q

Anti GD3

30
Q

Anti GM1

A

MMN with conduction block

31
Q

Anti-AChR

32
Q

Anti-MUSK

A

MG - not seen in ocular variant

33
Q

Anti-LRP4

A

Mild-mod MG

34
Q

Anti-VGCC

35
Q

Anti-Hu (ANNA-1)

A

SCLC, neuroblastomas
Paraneoplastic cerebellar degeneration, limbic encephalitis, encephalomyelitis, subacute sensory neuronopathy, choreathetosis, myoclonus

36
Q

Anti-Yo

A

Ovarian and breast Ca
Paraneoplastic cerebellar degeneration

37
Q

Anti-Ma

A

Encephalomyelitis
Limbic encephalitis

38
Q

Anti-Ri (ANNA-2)

A

Opsoclonus myoclonus snyndrome

39
Q

Anti-Tr

A

Paraneoplastic cerebellar syndrome

40
Q

Anti-amphiphysin

A

Stiff person syndrome
Paraneoplastic cerebellar

41
Q

Anti-GAD

A

Breast, CRC, SCLC
Stiff person syndrome
Type 1 DM

42
Q

Anti-NMDAr

A

Anti-NMDA receptor encephalitis
Prodromal symptoms followed by multistage progression:
- Psychiatric manifestations
- Sleep disorders
- Memory deficits
- Seizures
- Decreased LOC, stupor with catatonic features
- Frequent dyskinesias
- Autonomic instability
- Language dysfunction

43
Q

Anti-NMO (aquaporin-4)

A

Neuromyelitis optica

44
Q

Anti-LG1

A

Faciobrachial dystonic seizures
Memory disturbances
Confusion
Seizures

45
Q

Anti-Caspr2

A

Limbic encephalitis (Morvan syndrome)
Neuromyotonia
Memory loss and confusion
Sleep disturbances
Autonomic instability

46
Q

Anti-GABA-A

A

Rapidly progressive encephalitis
Refractory seizures, status epilepticus, and/or epilepsia partialia continua

47
Q

Anti cardiolipin

48
Q

Anti beta 2 glycoprotein 1

49
Q

Anti-PF4

50
Q

Anti-TPO

A

Hashimoto’s thyroiditis
Grave’s disease

51
Q

Anti-TgAbs

A

Hashimoto’s thyroiditis

52
Q

Anti-TRAbs

A

Graves’ disease

53
Q

Anti-PLA2R

A

Membranous GN

54
Q

Anti-THSF7A

A

Membranous GN (in patients with negative anti-PLA2R)

55
Q

suPAR

56
Q

Anti-GBM

A

Goodpastures

57
Q

What is associated with alpha synuclein?

A

Parkinson’s
MSA
LBD

58
Q

What are tauopathies?

A

Alzheimer’s
PSP
CBS
FTD

59
Q

What gene is associated with FTD?

A

TARDBP gene

60
Q

Antibodies associated with type 1 AIH

A

ANA, anti-SMA, anti-SLA

61
Q

Antibodies associated with type 2 AIH

A

Anti-LKM1
ALC-1

62
Q

Autopsy findings in FTD-ALS

A

TDP-43 protein

BPT Flashcards (32 decks)

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