Antibodies/Biopsy findings Flashcards
Anti-Ro
SLE
Neonatal heart block
Primary Sjogren’s
Anti-La
Primary Sjogrens
Anti-centromere
CREST syndrome
Limited sclerosis
Anti-dsDNA
SLE
Anti-Jo1
Inflammatory myopathy
Anti-U1-RNP
MCTD
Anti-Sm
Specific for SLE
Associated with CNS lupus, GN, African American, Poor prognosis
Anti-topoisomerase (Anti-Scl70)
Diffuse sclerosis
Higher risk of IPF
Anti-histone
SLE
Drug induced lupus
Anti-CCP
RA
Rheumatoid factor
RA
SLE
Anti-thrombin
SLE
c-ANCA (PR3)
GPA
p-ANCA (MPO)
MPA
EGPA
Systemic vasculitides
Primary sclerosing cholangitis
Ulcerative colitis
Anti-SRP
Polymyositis
IMNM
Anti-RNA polymerase III
Renal crisis in systemic sclerosis
Anti-Ro52
Systemic sclerosis (2nd most common antibody after anti-SCL70)
ILD
Dermatomyositis
Anti-p155
Dermatomyositis
Associated with malignancy and more severe cutaneous involvement
Anti-HMGCR
Statin induced necrotising mysotisi
BAFF + IL-6
GCA
PMR
Anti-tTG
Coeliac diseaseA
Anti-eTG
Dermatitis herpetiformis
Anti-actin
Coeliac
Anti-LKM1
type 2 autoimmune hepatitis
Anti-SMA
Chronic autoimmune hepatitis
AMA
Primary biliary cirrhosis
AIH type 1
Anti Saccharomyces cerevisiae antibody
Crohn’s disease
Anti GQ1B
MFS
Anti GD3
AMAN
Anti GM1
MMN with conduction block
Anti-AChR
MG
Anti-MUSK
MG - not seen in ocular variant
Anti-LRP4
Mild-mod MG
Anti-VGCC
LEMS
Anti-Hu (ANNA-1)
SCLC, neuroblastomas
Paraneoplastic cerebellar degeneration, limbic encephalitis, encephalomyelitis, subacute sensory neuronopathy, choreathetosis, myoclonus
Anti-Yo
Ovarian and breast Ca
Paraneoplastic cerebellar degeneration
Anti-Ma
Encephalomyelitis
Limbic encephalitis
Anti-Ri (ANNA-2)
Opsoclonus myoclonus snyndrome
Anti-Tr
Paraneoplastic cerebellar syndrome
Anti-amphiphysin
Stiff person syndrome
Paraneoplastic cerebellar
Anti-GAD
Breast, CRC, SCLC
Stiff person syndrome
Type 1 DM
Anti-NMDAr
Anti-NMDA receptor encephalitis
Prodromal symptoms followed by multistage progression:
- Psychiatric manifestations
- Sleep disorders
- Memory deficits
- Seizures
- Decreased LOC, stupor with catatonic features
- Frequent dyskinesias
- Autonomic instability
- Language dysfunction
Anti-NMO (aquaporin-4)
Neuromyelitis optica
Anti-LG1
Faciobrachial dystonic seizures
Memory disturbances
Confusion
Seizures
Anti-Caspr2
Limbic encephalitis (Morvan syndrome)
Neuromyotonia
Memory loss and confusion
Sleep disturbances
Autonomic instability
Anti-GABA-A
Rapidly progressive encephalitis
Refractory seizures, status epilepticus, and/or epilepsia partialia continua
Anti cardiolipin
APLS
Anti beta 2 glycoprotein 1
APLS
Anti-PF4
HITS
Anti-TPO
Hashimoto’s thyroiditis
Grave’s disease
Anti-TgAbs
Hashimoto’s thyroiditis
Anti-TRAbs
Graves’ disease
Anti-PLA2R
Membranous GN
Anti-THSF7A
Membranous GN (in patients with negative anti-PLA2R)
suPAR
FSGS
Anti-GBM
Goodpastures
What is associated with alpha synuclein?
Parkinson’s
MSA
LBD
What are tauopathies?
Alzheimer’s
PSP
CBS
FTD
What gene is associated with FTD?
TARDBP gene
Antibodies associated with type 1 AIH
ANA, anti-SMA, anti-SLA
Antibodies associated with type 2 AIH
Anti-LKM1
ALC-1
Autopsy findings in FTD-ALS
TDP-43 protein