Antibodies/Biopsy findings

Question 1

Anti-Ro

Answer 1

SLE
Neonatal heart block
Primary Sjogren’s

Question 2

Anti-La

Answer 2

Primary Sjogrens

Question 3

Anti-centromere

Answer 3

CREST syndrome
Limited sclerosis

Question 4

Anti-dsDNA

Answer 4

SLE

Question 5

Anti-Jo1

Answer 5

Inflammatory myopathy

Question 6

Anti-U1-RNP

Answer 6

MCTD

Question 7

Anti-Sm

Answer 7

Specific for SLE
Associated with CNS lupus, GN, African American, Poor prognosis

Question 8

Anti-topoisomerase (Anti-Scl70)

Answer 8

Diffuse sclerosis
Higher risk of IPF

Question 9

Anti-histone

Answer 9

SLE
Drug induced lupus

Question 10

Anti-CCP

Answer 10

RA

Question 11

Rheumatoid factor

Answer 11

RA
SLE

Question 12

Anti-thrombin

Answer 12

SLE

Question 13

c-ANCA (PR3)

Answer 13

GPA

Question 14

p-ANCA (MPO)

Answer 14

MPA
EGPA
Systemic vasculitides
Primary sclerosing cholangitis
Ulcerative colitis

Question 15

Anti-SRP

Answer 15

Polymyositis
IMNM

Question 16

Anti-RNA polymerase III

Answer 16

Renal crisis in systemic sclerosis

Question 17

Anti-Ro52

Answer 17

Systemic sclerosis (2nd most common antibody after anti-SCL70)
ILD
Dermatomyositis

Question 18

Anti-p155

Answer 18

Dermatomyositis
Associated with malignancy and more severe cutaneous involvement

Question 19

Anti-HMGCR

Answer 19

Statin induced necrotising mysotisi

Question 20

BAFF + IL-6

Answer 20

GCA
PMR

Question 21

Anti-tTG

Answer 21

Coeliac diseaseA

Question 22

Anti-eTG

Answer 22

Dermatitis herpetiformis

Question 23

Anti-actin

Answer 23

Coeliac

Question 24

Anti-LKM1

Answer 24

type 2 autoimmune hepatitis

Question 25

Anti-SMA

Answer 25

Chronic autoimmune hepatitis

Question 26

AMA

Answer 26

Primary biliary cirrhosis AIH type 1

Question 27

Anti Saccharomyces cerevisiae antibody

Answer 27

Crohn's disease

Question 28

Anti GQ1B

Answer 28

MFS

Question 29

Anti GD3

Answer 29

AMAN

Question 30

Anti GM1

Answer 30

MMN with conduction block

Question 31

Anti-AChR

Answer 31

MG

Question 32

Anti-MUSK

Answer 32

MG - not seen in ocular variant

Question 33

Anti-LRP4

Answer 33

Mild-mod MG

Question 34

Anti-VGCC

Answer 34

LEMS

Question 35

Anti-Hu (ANNA-1)

Answer 35

SCLC, neuroblastomas Paraneoplastic cerebellar degeneration, limbic encephalitis, encephalomyelitis, subacute sensory neuronopathy, choreathetosis, myoclonus

Question 36

Anti-Yo

Answer 36

Ovarian and breast Ca Paraneoplastic cerebellar degeneration

Question 37

Anti-Ma

Answer 37

Encephalomyelitis Limbic encephalitis

Question 38

Anti-Ri (ANNA-2)

Answer 38

Opsoclonus myoclonus snyndrome

Question 39

Anti-Tr

Answer 39

Paraneoplastic cerebellar syndrome

Question 40

Anti-amphiphysin

Answer 40

Stiff person syndrome Paraneoplastic cerebellar

Question 41

Anti-GAD

Answer 41

Breast, CRC, SCLC Stiff person syndrome Type 1 DM

Question 42

Anti-NMDAr

Answer 42

Anti-NMDA receptor encephalitis Prodromal symptoms followed by multistage progression: - Psychiatric manifestations - Sleep disorders - Memory deficits - Seizures - Decreased LOC, stupor with catatonic features - Frequent dyskinesias - Autonomic instability - Language dysfunction

Question 43

Anti-NMO (aquaporin-4)

Answer 43

Neuromyelitis optica

Question 44

Anti-LG1

Answer 44

Faciobrachial dystonic seizures Memory disturbances Confusion Seizures

Question 45

Anti-Caspr2

Answer 45

Limbic encephalitis (Morvan syndrome) Neuromyotonia Memory loss and confusion Sleep disturbances Autonomic instability

Question 46

Anti-GABA-A

Answer 46

Rapidly progressive encephalitis Refractory seizures, status epilepticus, and/or epilepsia partialia continua

Question 47

Anti cardiolipin

Answer 47

APLS

Question 48

Anti beta 2 glycoprotein 1

Answer 48

APLS

Question 49

Anti-PF4

Answer 49

HITS

Question 50

Anti-TPO

Answer 50

Hashimoto's thyroiditis Grave's disease

Question 51

Anti-TgAbs

Answer 51

Hashimoto's thyroiditis

Question 52

Anti-TRAbs

Answer 52

Graves' disease

Question 53

Anti-PLA2R

Answer 53

Membranous GN

Question 54

Anti-THSF7A

Answer 54

Membranous GN (in patients with negative anti-PLA2R)

Question 55

suPAR

Answer 55

FSGS

Question 56

Anti-GBM

Answer 56

Goodpastures

Question 57

What is associated with alpha synuclein?

Answer 57

Parkinson's MSA LBD

Question 58

What are tauopathies?

Answer 58

Alzheimer's PSP CBS FTD

Question 59

What gene is associated with FTD?

Answer 59

TARDBP gene

Question 60

Antibodies associated with type 1 AIH

Answer 60

ANA, anti-SMA, anti-SLA

Question 61

Antibodies associated with type 2 AIH

Answer 61

Anti-LKM1 ALC-1

Question 62

Autopsy findings in FTD-ALS

Answer 62

TDP-43 protein